Purpose This study aims to focus on usage of Al2O3/water nanofluid as working fluid in a combi boiler. The plate heat exchanger located at the bottom of the combi boiler has been used for heating the domestic water in the present study. Al2O3/water nanofluid has also been used in obtaining of the heat energy provided from combustion. Therefore, thermal performance of Al2O3/water has been determined by comparing water and nanofluid-water mixture. The present study also investigates heat transfer rates as numerical and experimental for varying cold side outlet temperatures, comparatively. Design/methodology/approach The present study has included both experimental and numerical methodologies. The experimental setup consists of main heat exchanger, atmospheric burner, circulation pump and plate-type heat exchanger in which the Al2O3/water nanofluid was used as working fluid to heat the domestic water. In the numerical part of the study, a commercial computational fluid dynamic code has been used to model heat rate and thermal efficiency of the heat exchanger used. Findings It has been concluded that the predicted results are in satisfactorily good agreement with the measured data. In the experimental part of the study, the flow rate of Al2O3/water nanofluid was kept constant during the experiments. The flow rates of the water by which the heated Al2O3/water nanofluid mixture was cooled via the plate heat exchanger have been changed as 3, 4, 5 and 6 lpm. The domestic water temperatures that were kept constant have also been changed as 40°C, 45°C, 50°C, 55°C and 60°C. It has been concluded that the Al2O3/water nanofluid thermal efficiency has been 16 per cent better than pure water. Originality/value The main originality of the present study is that thermal efficiency of the plate-type heat exchanger when Al2O3/water mixture nanofluids are used as there are limited studies related to the usage of Al2O3/water mixture nanofluids in the plate-type heat exchanger not only experimental but also numerical methodologies.