An infection of the human oral cavity that is primarily fungal is called Candida-associated denture stomatitis. Erythema of the palate and alveolar ridges are symptoms of denture stomatitis, which is a persistent inflammatory condition of the mucosa supporting dentures. So that a red pigment made by Serratia marcescens and designated as prodigiosin was purified by silica gel column chromatography with a yield of 3.7 g/l after being extracted at higher concentrations using methanol with a yield of 3.3 g/l. Additionally, a UV scan of the pigment revealed that its highest absorbance occurred at 535 nm, and thin layer chromatography revealed that it had an Rf value of 0.86 when compared to standard. In cases of oral or denture stomatitis, Candida albicans was the dominating species followed by C. tropicalis, C. parapsilosis and C. dubliniensis, respectively. Checking for the development of biofilms by Candida spp. revealed that C. albicans and C. tropicalis produced biofilm but in different levels. The most effective source of biofilm production was C. albicans isolates. Candida species were prevented from forming biofilms by the purified prodigiosin. Candida albicans isolates had a greater proportion of biofilm inhibition, ranging from 63 to 82%. In contrast, the percentage of inhibition for isolates of C. tropicalis varied between 57 and 61%. Prodigiosin has a favorable advantage for potential usage in the dental sector since it stops and prevents the growth of biofilm.
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