Background: Polycystic ovary syndrome (PCOS) is one of the most common, heterogeneous endocrine disorder of reproductive aged women. Association of autonomic impairment and elevated oxidative stress may predispose these patients to increased cardiovascular risks. Objective: To evaluate the relationship between cardiac autonomic nerve function (CANF) and oxidative stress in patients with PCOS. Methods: This cross sectional study was conducted in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from September, 2018 to August, 2019. For this study, 30 newly diagnosed PCOS patients aged 20-35 years were recruited and similar age, body mass index (BMI) 30 apparently healthy, regularly menstruating women were enrolled as control. CANF was assessed by analyzing time domain measures of Heart Rate Variability (HRV). HRV data were recorded by a digital data acquisition device, Powerlab 8/35 (AD instruments, Australia). For evaluation of oxidative stress, plasma catalase and plasma Malondialdehyde (MDA) levels were measured. Statistical analysis was done by unpaired “t” test and Pearson’s correlation test as applicable. Results: In this study, resting pulse rate, systolic blood pressure (SBP), diastolic blood pressure (DBP) were significantly higher (p<0.001, p<0.01, p<0.01 respectively) and standard deviation of the RR intervals (SDRR) (p<0.01), mean R-R interval, standard deviation of the difference between successive RR intervals (SDSD), square root of mean squared differences of successive RR intervals (RMSSD), proportion of RR interval with duration >50 ms (pRR50%) were significantly lower (p<0.001) in PCOS than healthy controls. In addition, plasma catalase was significantly lower (p<0.01) and plasma MDA was significantly higher (p<0.001) in PCOS patients compared to controls. On correlation analysis, mean heart rate, SDRR, SDSD, RMSSD and pRR50% showed negative correlation with plasma catalase and plasma MDA (p<0.05) in PCOS patients but these were not significant. Conclusion: The present study reveals that reduced parasympathetic activity in PCOS patients may be related to oxidative stress. J Bangladesh Soc Physiol. 2019, December; 14(2): 82-88
Background: Polycystic ovary syndrome (PCOS) is a very common reproductive hormone disorder. Altered cardiovagal autonomic modulation and oxidative stress may predispose PCOS patients to increased cardiovascular morbidity. Objective: To assess the relationship between parasympathetic reactivity and oxidative stress in patients with PCOS. Methods: This crosssectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka from September 2018 to August 2019 on 35 newly diagnosed obese (BMI ≥25kg/m2) PCOS patients aged 20-35 years. Age and BMI matched 35 apparently healthy women were also enrolled as control. Three noninvasive conventional autonomic function tests, such as heart rate response to deep breathing, standing and the Valsalva maneuver, were used for evaluation of parasympathetic reactivity. For assessment of oxidative stress, plasma malondialdehyde level (oxidant) and plasma catalase level(antioxidant) were measured in all subjects by spectrophotometry. Data were expressed as mean± SD. For statistical analysis Independent sample “t” test, Pearson’s correlation test and multiple regression analysis were done as applicable. Results: In this study PCOS patients had significantly higher (p<0.01)resting heart rate, systolic and diastolic blood pressure than that of healthy control. But Expiration: Inspiration ratio, Expiration:Inspiration difference and 30:15 ratio during standing were significantly lower (p<0.001, p<0.01 and p<0.05 respectively) in PCOS compared to control. In addition, plasma catalase level was significantly lower (p<0.01)and plasma malondialdehyde level significantly higher (p<0.001) in PCOS in comparison to healthy control. Multiple regression analysis showed plasma catalase as a significant positive predictor (p<0.05) of the Valsalva ratio in PCOS. Also, Valsalva ratio showed significant negative association (p<0.05) with plasma malondialdehyde (p<0.01)in PCOS. Conclusion: Based on these results it is concluded that impaired parasympathetic reactivity showed inverse relationship with oxidative stress in PCOS. J Bangladesh Soc Physiol. 2019, December; 14(2): 48-55
Background: Polycystic ovary syndrome (PCOS) is a very common reproductive endocrine disorder. Altered cardiovascular autonomic modulation and oxidative stress may predispose PCOS patients to cardiac events in the long term. Objective: To assess the relationship between sympathetic autonomic reactivity and oxidative stress in patients with polycystic ovary syndrome. Methods: This cross-sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from September 2018 to August 2019 on 35 newly diagnosed obese (BMI ≥25kg/m2) PCOS patients aged 20-35 years. Age and BMI matched 35 apparently healthy subjects were also enrolled. Two noninvasive conventional autonomic function tests, such as systolic blood pressure (SBP) fall during active standing and diastolic blood pressure (DBP) rise during sustained handgrip were conducted on all subjects for evaluation of sympathetic reactivity. For assessment of oxidative stress, plasma malondialdehyde level as oxidant and plasma catalase level as antioxidant were measured in all subjects by spectrophotometry. For statistical analysis Independent sample “t” test, Pearson’s correlation test and multiple regression analysis were done. Results: In this study PCOS patients had significantly higher resting heart rate, SBP and DBP than healthy control (p<0.01). Fall of SBP during standing was significantly lower (p<0.05) while rise of DBP during sustained handgrip was significantly higher (p<0.05) in PCOS compared to healthy control. Plasma catalase level was significantly lower (p<0.01) and plasma malondialdehyde level significantly higher (p<0.001) in PCOS in comparison to healthy control. On correlation analysis, rise of DBP showed significant negative correlation (p<0.05) with plasma catalase level in PCOS. On multiple regression analysis rise of DBP showed significant negative (p<0.01) association with plasma catalase and significant positive (p<0.01) association plasma malondialdehyde in PCOS. Conclusion: Based on these results it is concluded that measures of sympathetic reactivity were related to oxidative stress in PCOS. J Bngladesh Soc Physiol 2021;16(1): 61-69
Background: Polycystic ovary syndrome (PCOS) is a well recognized reproductive hormone disorder. It is often associated with dysautonomia and increased oxidative stress Objective: To assess the relationship between cardiac autonomic nerve function (CANF) and oxidative stress in patients with PCOS. Methods: This cross sectional study enrolled 30 newly diagnosed PCOS patients 20-35 years of age and 30 apparently healthy, regularly menstruating women of similar age and BMI. The patients were enrolled from outpatient Department of Endocrinology, BSMMU, Dhaka. CANF was assessed by poincare analysis of RR interval, a non linear method of Heart Rate Variability (HRV) analysis. HRV data of all subjects were recorded by a digital data acquisition device, Power lab 8/35, AD instruments, Australia, with lab chart software analysis. Oxidative stress was assessed by plasma catalase and plasma Malondialdehyde (MDA) levels. For statistical analysis unpaired “t” test and Pearson’s correlation test were used. Results: In this study, resting pulse rate, systolic blood pressure(SBP), diastolic blood pressure(DBP) were significantly higher (p<0.001, p<0.01, p<0.01 respectively) and standard deviation of the short term RR interval variability (SD1), ratio of short term and long term variability (SD1/SD2) ratio were significantly lower (p<0.001) in PCOS than those of healthy controls. In addition, plasma catalase levels was significantly lower (p<0.01) and plasma MDA levels was significantly higher (p<0.001) in PCOS patients compared to controls. On correlation analysis, SD1 showed negative correlation with plasma catalase and plasma MDA levels (p>0.05) in PCOS patients. In addition SD1/SD2 ratio showed positive correlation with plasma catalase and negative correlation with plasma MDA levels (p>0.05) in these group of patients. But all these correlations were statistically not significant. Conclusion: The present study reveals association of autonomic dysfunction and higher oxidative stress with PCOS but it failed to show evidence for any interrelationship between them. J Bngladesh Soc Physiol 2021;16(1): 88-94
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