These results suggest that the ethyl acetate fraction of Globimetula braunii leaves extract possesses psychoactive compound that may be useful in the management of petit mal epilepsy and lend credence to the ethnomedical use of the plant in the management of epilepsy.
Dichlorvos; organophosphorus pesticide is among the most widely used pesticides for insect control. In Nigeria and most other developing countries it is used indiscriminately by people with little or no knowledge of its toxic effects as a household and agricultural insecticide. The acute effect and antidotal therapy of dichlorvos was studied in laboratory animals. The LD 50 in rats was determined to be 28.28 mg/kg i.p, with acute poisoning symptoms of micturation, restlessness, pupil constriction, respiratory distress and convulsion. Atropine was found to be the most effective antidote as it significantly (P < 0.05 -0.001) reduced all symptoms of poisoning and gave 100% survival rate. There was however no significant difference between the animals treated with atropine alone and those treated with combination of atropine and diazepam. The results also showed that diazepam significantly reduced symptoms like restlessness (P < 0.05), pupil constriction and convulsion (P < 0.001).
Aim:The current study was carried out to evaluate the hepatoprotective effects of aqueous extract of Adansonia digitata fruit pulp on carbon tetrachloride (CCl 4 ) induced liver damage in rats. Place and Duration of Study: Methodology: A. digitata fruit pulp was extracted by maceration using water; and a concentration of 100 mg/ml was used. Two doses of the aqueous extract (200 mg/kg and 300 mg/kg) and Livoline Sa'id et al.; AJBGMB, 3(3): 12-21, 2020; Article no.AJBGMB.54697 13 (25 mg/kg) were used to investigate their hepatoprotective effects on CCl 4 -induced hepatotoxicity in rats. Results: The two doses of the plant extract showed dose-dependent hepatoprotective effect on CCl 4 -induced hepatotoxicity, as evident by the significant reduction (P<0.05) in serum levels of AST, ALT, ALP and bilirubin along with the improved histopathological liver sections compared to CCl 4treated animals. Conclusion: Due to its hepatoprotective potentials, A. digitata extract may be used to develop standard treatment drugs against some liver disorders when it is further evaluated through extensive researches.
Original Research Article
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