Studies have shown that healthcare professionals struggling with epidemics develop symptoms of post‐traumatic stress disorder. The aim of this study is to show how often and severely erectile dysfunction, one of the components of post‐traumatic stress disorder, is seen among healthcare professionals during COVID‐19 outbreak. The Impact of Event Scale‐Revised (IES‐R) and the Index of Erectile Function‐5 (IIEF‐5) were applied to 159 male healthcare professionals working in COVID‐19 units and a control group of 200 people. Healthcare professional group was divided into subgroups according to occupation (physician, nurse), age‐group (18–25, 26–30, >30), marital status and unit of work (Suspected Patient Area, Diagnosed Patient Area). Both stress disorder and erectile dysfunction were seen at higher rates in healthcare professionals group (p < .001). The median IIEF‐5 scores of nurses, married subjects and those working in the Diagnosed Patient Area, were found to be higher (p < .001, p = .014, p = .011 respectively). During the COVID‐19 outbreak, healthcare professionals are exposed to psychological trauma and their sexual function may be negatively affected. The measures to be taken are important to estimate which groups are more affected.

Purpose:To investigate the prognostic role of preoperative albumin/globulin ratio (AGR) in predicting disease-free survival (DFS) and overall survival (OS) in localized and locally advanced clear cell renal cell carcinoma (RCC) patients.Patients and Methods:162 patients who met the criteria specified were included in the study. The DFS and OS ratios were determined using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were performed to determine the prognostic factors affecting DFS and OS.Results:Median follow-up period was 27.5 (6-89) months. There was a statistically significant relationship between low AGR and high pathological tumor (pT) stage, presence of collecting system invasion, presence of tumor necrosis, and a high platelet count (p = 0.012, p = 0.01, p = 0.001, and p = 0.004, respectively). According to the Kaplan-Meier survival analysis, both OS and DFS were found to be significantly lower in the low AGR group (p = 0.006 and p = 0.012). In the multivariate Cox regression analysis, collecting system invasion and tumor necrosis were found to be independent prognostic factors in predicting OS and pT stage was found to be an independent prognostic factor in predicting DFS (HR: 4.08, p = 0.043; HR: 8.64, p = 0.003 and HR: 7.78, p = 0.041, respectively).Conclusion:In our study, low AGR was found to be associated with increased mortality and disease recurrence in localized and locally advanced RCC.

Objective To compare the clinically significant prostate cancer (csPC)‐detecting results of transperineal and transrectal targeted biopsy (TPTB and TRTB, respectively) by performing matching analysis. Patients and Methods This study has used the PC and prostate biopsy database from the Turkish Urooncology Association. A total of 1143 patients with Prostate Imaging–Reporting and Data System (PI‐RADS) with ≥3 lesions on multiparametric magnetic resonance imaging (mpMRI) and who had received a software‐guided transperineal/transrectal MRI/transrectal ultrasound (TRUS) fusion prostate biopsy with concomitant standard systematic 12‐core biopsy were included in this study. csPC detection rates of the TP and TR approaches were compared following Mahalanobis distance matching within propensity score caliper method. The following four variables were selected as covariates for the matching procedure: age, digital rectal examination findings, PSA density, and the index lesion PI‐RADS score. Results The matched sample included 508 TR and 276 TP patients. In both the TP and the TR groups, targeted biopsy was superior to systematic biopsy in detecting csPC (27.5% vs. 24.6%, p < 0.001 and 19.5% vs. 16.3%, p < 0.0001, respectively). Both TPTB and TP systematic biopsy was found to be superior to TRTB and TR systematic biopsy in terms of csPC detection (27.5% vs. 19.5%, p = 0.012 and 24.6% vs. 16.3%, p = 0.006). In patients with an anterior index lesion, an apical index lesion, and a larger prostate, the superiority of TPTB to TRTB was found to be more prominent in terms of csPC detection (37.8% vs. 18.3%, p = 0.044; 34.6% vs. 14.7%, p = 0.002; and 25% vs. 5.1%, p = 0.033, respectively). Conclusion Targeted biopsy was found to be superior to systematic biopsy in detecting csPC in both the TP and the TR approaches. The TP approach is preferred because of its clear superiority in detecting csPC in targeted biopsy, especially in patients with anterior and apical lesions and with larger prostates.

Background: The aim of this study was to evaluate the role of histopathological and biochemical parameters in the prediction of the presence and number of PSMA positive lesions consistent with the metastatic spread of prostate cancer on 68 Ga-PSMA PET images.Methods: Biochemical, histopathological and imaging data of 302 prostate cancer patients who underwent 68 Ga-PSMA-11 PET/CT or PET/MR imaging for primary staging were retrospectively analyzed. Patients were divided into two groups as "PET positive" and "PET negative" according to the presence of pathologic extraprostatic PSMA involvement. "PET positive" patients were additionally divided into two groups: oligometastatic (1-3 metastatic lesion) and multimetastatic (>3 metastatic lesions).Results: The mean age of patients was 66.8 ± 7.6 years. Imaging modality was PET/ MR in 223 (73.8%) and PET/CT in 79 (26.2%) of patients. Total PSA, PSA density (PSAD), ALP, and tumor ratio in biopsy specimens were found to be significantly higher in "PET positive" group compared to "PET negative" group and in multimetastatic group compared to oligometastatic group. PET positivity was observed in 3.8% of the low-intermediate risk groups (ISUP 1-3 and total PSA ≤ 20 ng/ml and PSAD < 0.15 ng/ml/cc). This ratio was 46% in the high-risk group (ISUP 4-5 or total PSA > 20 ng/ml or PSAD ≥ 0.15 ng/ml/cc) with a relative risk of 12 (p < .001). The prediction models to predict the PET positivity and the presence of distant metastasis had AUCs of 0.901 and 0.925, respectively; with ALP, total PSA, and tumor ratio in needle biopsy specimen as significant independent predictors (p < .05).Conclusions: In this study, 68 Ga-PSMA-11 PET positivity was significantly higher in the high-risk patient group than in the low-intermediate risk groups. The prediction models used for predicting the PET positivity and the presence of distant metastasis on PET imaging were successful with high discriminatory powers. In addition to total

Anterior urethral valve (AUV) is a rare but well-defined congenital anomaly. AUV can be isolated or occur in association with anterior urethral diverticulum (AUD). Here, we present the first pediatric case report of AUV and AUD which is complicated with an intradiverticular stone. We also review the literature involving AUV with AUD cases.

INTRODUCTION ÖZ GİRİŞ ve AMAÇ: Bu çalışmada uzmanlık eğitimi sonrası PNL'ye ilk kez 2. basamak devlet hastanesinde başlayan bir cerrahın bu cerrahide yetkinliğe ulaşıldığı düşünülen ilk 60 vakasının sonuçlarını retrospektif olarak değerlendirerek PNL'ye 2. basamak hastanelerinde güvenli ve etkin bir şekilde başlanabileceğini değerlendirmek amaçlandı. YÖNTEM ve GEREÇLER: Çalışmaya perkütan nefrolitotomi yapılan 60 renal ünite (58 hasta) dahil edildi. Tüm hastalara prone pozisyonda standart (30Fr) perkütan nefrolitotomi 25 Fr rijit nefroskop ve pnömotik litotriptör ile uygulandı. Yaş, cinsiyet, opere edilen taraf gibi hastaya ilişkin veriler ile birlikte taş yükü, taş sayısı, taşın lokalizasyonu, renal akses lokalizasyonu ve sayısı, operasyon süresi, postop komplikasyonlar, kan transfüzyonu gereksinimi, başarı oranı, hastanede kalış süresi ve ek tedavi gereksinimleri gibi veriler retrospektif olarak toplandı. BULGULAR: Hastaların 43 (%74) 'ü erkek, 15 (%26)'i kadın olup yaş ortalaması 47,8 ± 10,5 (22-67) idi. Taşların 20 (%33,3)'si basit taşlarken 40 (%66,7)'ı kompleks taşlardı. Ortalama taş yükü 8,4 cm2 ve ortalama Hounsfield Ünite (HU) 1121 ± 267 idi. Ortalama ameliyat süresi 125 ± 34 dakika idi. Hastalar ortalama 4,4 ± 2 (2-12) gün hastanede yattı. %26,7 renal ünitede komplikasyon görülürken Clavien grade 4 ve 5 komplikasyon görülmedi. Ek girişimlerle birlikte %90 başarı (taşsızlık + klinik önemsiz rezidüel fragmanlar) elde edildi. TARTIŞMA ve SONUÇ: PNL'ye 2. basamak devlet hastanelerinde güvenli ve etkin bir şekilde literatürle uyumlu komplikasyon ve başarı oranları ile başlanabileceği düşünülmekte olup konu ile ilgili prospektif randomize kontrollü çalışmalara ihtiyaç vardır. ABSTRACT INTRODUCTION:The aim of this study was to evaluate the results of the first 60 patients of a surgeon who started performing PNL for the first time in a state hospital after the residency and to evaluate that PNL can be started safely and effectively in 2nd stage hospitals. METHODS: Sixty renal units (58 patients) undergoingpercutaneous nephrolithotomy were included in the study. All patients underwent standard (30Fr) percutaneous nephrolithotomy with 25 Fr rigid nephroscope and pneumatic lithotriptor in the prone position. The data was evaluated retrospectively in terms of patients age, gender, operated side and stone burden, stone number, stone localization, location and number of renal accesses, duration of operation, complications, blood transfusion requirement, success rate, hospital stay and additional treatment requirements.RESULTS: 43 (74%) of patients were male and 15 (26%) were female and the mean age was 47.8 ± 10.5 (22-67). Of the stones, 20 (33.3%) were simple stones and 40 (66.7%) were complex stones. The mean stone burden was 8.4 cm2 and the mean Hounsfield unit (HU) was 1121 ± 267. The mean operative time was 125 ± 34 minutes. The patients were hospitalized for an average of 4.4 ± 2 (2-12) days. Complications were observed in 26.7% renal unit and no Clavien grade 4 and 5 complications. 90% success (stone free + cl...

Objective: To evaluate the diagnostic accuracy of the 68 gallium ( 68 Ga) prostatespecific membrane antigen (PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI) and multiparametric MRI (mpMRI) by region-based comparison of index tumour localisations using histopathological tumour maps of patients who underwent radical prostatectomy because of clinically significant prostate cancer. Patients and Methods:The study included 64 patients who underwent radical prostatectomy after primary staging with mpMRI and 68 Ga-PSMA PET/MRI. Diagnostic analysis was performed by dividing the prostate into four anatomic regions as left/ right anterior and left/right posterior. The extension of the lesions in mpMRI and the pathological uptake in 68 Ga-PSMA PET/MRI were matched separately for each region with the extension of the index tumour into each region. Results:The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and the accuracy of mpMRI

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