BACKGROUND: Gestational trophoblastic diseases (GTDs) are treatable rare tumors with wide distribution. The estimated incidence of GTDs varies dramatically between different regions globally. In early pregnancy, there may be high human chorionic gonadotropin (HCG) concentrations, normal or slightly increased free T4 (fT4) and subnormal thyroid-stimulating hormone (TSH), causing hyperthyroidism ranging from subclinical to severe. Beta-HCG causes thyrotoxicosis through thyroid stimulation in patients with trophoblastic tumors. OBJECTIVE: To assess thyroid function among patients diagnosed with complete or partial hydatidiform mole, within the GTD spectrum. DESIGN AND SETTING: Cross-sectional study based on patients' medical records at Van University Hospital, Van, Turkey. METHODS: 50 patients monitored due to diagnoses of hydatidiform mole were included and were examined regarding thyroid function. Thyroid gland size and volume were measured using thyroid ultrasonography. Beta-HCG, TSH, fT4, free T3 (fT3), total T4 (TT4), total T3 (TT3), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and thyroglobulin levels were measured. RESULTS: Among these patients, 15 (30%) were diagnosed with complete hydatidiform mole and 35 (70%) with partial hydatidiform mole, according to pathology results. Those with complete hydatidiform mole were older (P = 0.003), with higher number of pregnancies (P = 0.032), lower TSH level (P = 0.011) and higher fT4 and TT4 levels (P = 0.04; P = 0.028), compared with partial hydatidiform mole patients. CONCLUSION: In hydatidiform mole patients, thyroid disease severity increases with age, parity, beta-HCG level and mole size. However, prospective multicenter studies on this topic are needed, with larger numbers of patients and closer monitoring. Thyroid function among women with gestational trophoblastic diseases. A cross-sectional study | ORIGINAL ARTICLE

Background: Sepsis is an important risk factor for the development of acute renal injury (ARI) among patients admitted to the intensive care unit (ICU). There are limited studies showing that increased uric acid level is an important risk factor for the development of ARI. The present study was carried out to find out whether increased basal uric acid levels play an important role in predicting the development of ARI and whether it could be used as a biomarker for this. Materials and Methods: This retrospective study included patients aged≥18 years who were admitted to the ICU of Yüzüncü Yıl University Medical Faculty Hospital from September 2018 to December 2020. Group 1 comprised 100 patients developing ARI and group 2 comprised 110 patients who did not develop ARI. Laboratory test values and Simplified Acute Physiologic Score II (SAPS II) data on the first day of ICU admission were obtained from archive records. Results: During the 10-day follow-up of patients included in the study, the ARI development rate was 57.3%. Basal serum uric acid levels were higher in group 1 compared to group 2 (P=0.001). Based on the results of the multivariate logistic regression analysis, basal serum uric acid values and albumin and SAPS II values had independent correlations with ARI (P<0.001). Conclusion: We believe that increased basal uric acid levels examined in patients admitted to the ICU with sepsis diagnosis may be an important biomarker for the prediction of ARI.