Airborne infection control measures are used extensively in health-care settings to curtail the spread of airborne infectious diseases. Few such measures are applied in public congregate spaces outside health facilities, such as those associated with public transport. In minibus taxis – a popular form of public transport in South Africa – poor ventilation creates conditions that allow for transmission of airborne diseases, particularly tuberculosis. In this study, we focused on developing quantitative ventilation profiles for the 16-seater Toyota Quantum Ses’fikile model commonly used in the Cape Town metropole. We studied the ventilation rates achievable in an occupied taxi under varying operational conditions, such as driving speed and open window configurations, which were based on observations made during preliminary taxi journeys. Two open-window configurations were found to provide ventilation rates close to or exceeding WHO recommended per-person requirements for high-risk clinical areas and are therefore likely to be effective in reducing the risk of tuberculosis transmission.