ÖZEkstrapulmoner küçük hücreli karsinomlar nadir, agresif seyirli ve sık metastaz yapan malign neoplazilerdir. Bu tümörler başlıca üst solunum yolu, özefagus ve ürogenital sistemde ortaya çıkar. Küçük hücreli prostat karsinomları tüm prostat kanserleri içinde %1'den daha az orandadır. Bunlar, daha önceden prostatik adenokarsinom tanısı almış ve androjen deprivasyon tedavisi uygulanan hastalarda da gelişebilir. Prostat kanserinde nöroendokrin diferansiasyonu yakalamak ve saf küçük hücreli karsinomu kötü diferansiye asiner adenokarsinomdan ayırt etmek önemlidir. Bu yazıda, 3 yıl önce prostat adenokarsinomu tanısı almış, androjen deprivasyon tedavisi uygulanmış küçük hücreli prostat karsinomu olgusu, ayırıcı tanı kriterleri, önemli histopatolojik ve immünohistokimyasal özellikleri, tedavi ve prognozu açısından literatür bilgileri eşliğinde sunulmaktadır. Keywords: Ekstrapulmoner, küçük hücreli karsinom, prostat ABSTRACTExtrapulmonary small cell carcinomas are rare, aggressive malignant neoplasms with frequent metastases. These tumors mainly occur in the upper respiratory tract, esophagus and urogenital system. Small cell carcinomas of the prostate constitute less than 1% percentage of all prostate cancers. They can also develop in patients with previously diagnosed prostatic adenocarcinoma and treated with androgen deprivation therapy. It is important to detect neuroendocrine differentiation and distinguish pure small cell carcinoma from poorly differentiated acinar adenocarcinoma. In this article, a case of prostatic small cell carcinoma that applied to androgen deprivation therapy because of a former diagnosis of prostatic adenocarcinoma three years ago, is presented with associated differential diagnosis, major histopathologic and immunohistochemical features, treatment and the prognosis and literature knowledge.
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