The incidence of a post-operative sore throat (POST) varied from 21%–100% in intubated patients. Numerous non-pharmacological and pharmacological measures have been used for attenuating POST with variable success. The aim of the present study was to compare the efficacy of amyl meta cresol-2,4-dichlorobenzyl alcohol (AMC-2,4-DCBA) lozenges against warm normal saline (0.9%) gargles versus control in preventing and treating POST after extubation of the patients who have undergone surgical procedures under general anaesthesia.This single-blind randomised controlled study was conducted in 120 patients. Group S patients received one honey and lemon-flavoured AMC-2,4-DCBA lozenge. Group G and Group C patients received warm normal saline and distilled water for gargling respectively. Assessment of POST was carried out at 1 h, 12 h and 24 h. The primary outcome measure was to compare the degree of sore throat whereas secondary outcome measure was to compare patient comfort in terms of relief of symptoms. Comparison of quantitative and qualitative variables was done using analysis of variance test and chi-square test/Fisher’s exact test respectively.There was no statistically significant difference between Group S, Group G and Group C in relation to Ramsay sedation score, supplemental analgesics given, three-point assessment score at 1 h, 12 h, and 24 h. AMC-2,4-DCBA lozenges offered the maximum benefit in terms of patient comfort of POST symptoms at the end of 24 h post-surgically. Amyl meta cresol-2,4-dichlorobenzyl alcohol lozenges and warm normal saline gargles did not show a significant benefit in relieving post-operative sore throat in the post-surgical period as compared to the placebo.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.