Malaria infection, which results due to the parasitic protozoan
Plasmodium
, has several known etiologies of hemolytic anemia as a possible complication in cases such as concurrent G6PD deficiency, severe parasitemia, or use of parenteral antimalarials. Although artemisinin-based antimalarial therapies are generally well-tolerated, several cases of severe post-artemisinin delayed hemolysis (PADH) have been recently reported, which present a diagnostic challenge, and affect morbidity and mortality in patients with malarial infection. We highlight the case of a young lady with
Plasmodium falciparum
severe parasitemia who developed hemolytic anemia after parenteral artesunate therapy.
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