Organic dyes are frequently used in various industries such as textiles, medicines, plastics, etc. and contribute as a major source of environmental pollutants, which leads to harmful effects on livings. Therefore, in this study, a Sn-doped CeO2-Fe2O3 photocatalyst was synthesized using the thermal decomposition method and applied for the effective degradation and removal of rhodamine B dye under solar irradiation. The as-synthesized catalyst was characterized by powder X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), Brunauer-Emmett-Teller (BET) and UV-vis diffuse reflectance (UV-vis DRS) techniques. The particle size of the photocatalyst was found 1-2 μm with a high surface area. The band gap energies of the catalyst narrowed to 2.2 eV after the Sn doping. The doping of Sn4+ ions into CeO2 lattice leads to the enhanced photocatalytic activity of CeO2-Fe2O3 composite by modified the Fermi levels of catalyst. The catalyst has shown a fast degradation rate under solar irradiance and is able to perform complete degradation of rhodamine B dye. The photocatalyst showed the COD removal up to 96% from the dye solution. Further, the scavenger test revealed the active species hydroxyl (•OH) and superoxide (O2 •−) radical are involved in the degradation of rhodamine B dye. The complete degradation of rhodamine B dye was studied and confirmed by high-performance liquid chromatography. A plausible mechanism is proposed for the degradation process and charge transfer during the degradation.
Diabetic mellitus is an emerging disease in Saudi Arabia. In this regard, a cross-sectional retrospective study was conducted to evaluate drug utilization pattern and the cost associated with non-insulin-dependent diabetes mellitus disease management in Saudi Arabia. Data retrieved from the electronic pharmacy records during the last one year were employed in this study. World Health Organization (WHO) Defined Daily Dose (DDD) method was employed to compute the daily price of each oral hypoglycaemic agent. The American Diabetes Association (ADA) guidelines and protocols were used to evaluate the level of adherence. A total of 17057 patients were enrolled in the study. Out of the 17057 patients enrolled in the study, 60.06 % (10246) were males and the rest females. In monotherapy, biguanides (metformin) were the most recommended and utilised drugs among 5673 patients (33.25%). The most commonly used drug combination was found to be sitagliptin+metformin (1754 units). The cost per unit dose was highest for liraglutide (A10BJ02) 258.32SR (68.79USD), and lowest for metformin (A10BA02) 0.49SR (0.13 USD). Metformin was the choice drug for the diabetes patients; biguanides (metformin) and DPP-4 (sitagliptins) were the most familiar established dose combination employed. Generic drugs should be used in order to reduce overall cost.
Objective This study is based on a retrospective cross-sectional study to assess the prescribing patterns and cost-utility analysis of management of childhood asthma in Saudi Arabia. Methods Prescription data were collected for 1 year from electronic records of pharmacy. The unit dose price was retrieved from pharmacy database and compared with daily price based on WHO Defined Daily Dose (DDD) and Saudi Initiative for Asthma (SINA). The cost of each drug is calculated from average prices of each unit dose of each prescription. Key findings In male children (57.98%), asthma was more common in comparison to female children (41.02%) at the studied hospital. Salbutamol (44.55%) was the most commonly prescribed medication followed by budesonide (30.97%) and montelukast (12.82%), whereas prednisolone (0.15%) was the least prescribed medication for the management of childhood asthma. It was found that fixed-dose combination of budesonide and formetrol prescribed for the longest duration of therapy (30 days) and imposed highest cost as well [197.10 SR (52.53 USD)] among all the prescribed medicine. Conclusion In this study, inhalation route is the most preferred one for management of asthma; this may be due to their fast therapeutic action. Salbutamol was the most popular drug for quick reliever therapy, while budesonide was the most favoured drug for childhood asthma management. Medication prescribed for the management of childhood asthma at the mentioned study centre adhere to SINA guideline.
Objectives Inappropriate use of antibiotics is a matter of concern worldwide as that may lead to antimicrobial drug resistance. The objective of current study was to assess drug utilization pattern and cost-effectiveness. Studies are conducted to analyze the pattern of antibiotics prescribing their adherence to standard guidelines and economic impact on the patients in order to promote their rational use. Methods The study was designed as a single-centred, cross-sectional retrospective pharmacy database study of prescribing patterns and cost-utility analysis of five most common antibiotics used in Saudi Arabia. Data for the period from 1 January 2019 to 31 December 2019 were used in the study. Demographic characteristics were demonstrated as frequencies and percentages (with Wilson 95% confidence intervals for proportions). The chi-square test (for P-value calculation) was used to compare the adherence of National Antimicrobial Guidelines for prescribing antibiotics in Saudi Arabia. Key findings The maximum number of patients was recorded from the age group of 18–35 years (35.97%) and minimum from 72 to 88 years (1.82%). The number of units prescribed was highest for amoxicillin, clavulanic acid (22487) to 42.93% of patients and was lowest for ciprofloxacin (4215) with 8.04%. The longest duration of therapy was for Cefdenir (7.23 days) and lowest for azithromycin (3.58 days). The cost was highest for Cefdenir 38.66SR (10.31USD), and lowest cost was estimated for Cefuroxime 12.43SR (3.31USD). Conclusions Our study declared that (amoxicillin with clavulanic acid) was used the most as first-line agents in treating bacterial infections due to their broad coverage against different microbes. Conducting laboratory tests to identify the type of microbe before prescribing could prevent the development of drug resistance and save the antibiotic for future. The cost-to-benefit analysis studies of antibiotics must be conducted for each indication that may promote their rational use.
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