Objectives: To determine the frequency of Hepatitis C infection in patients with ischemic Stroke at CMCH Larkana. Study Design: Cross-sectional study. Setting: Medical wards of Shaheed Mohtarma Benazir Bhutto Medical University Larkana. Period: From January 2018 to December 2018. Material & Methods: This study was conducted on 125 diagnosed ischemic stroke patient with age >18 years or both genders. Patients with sudden history of partial or complete weakness of half the body persisting for more than 24 hours and clinical examination supporting reduced power and presence of focal sign and CT brain showing hypodense area in respected blood supply. Patients were considered suffering from Hepatitis C who were reactive to anti HCV on second generation ELISA. Results: We surveyed 125 patients admitted with clinical diagnosis of ischemic stroke after exclusion criteria with mean age of 54.53 ± 10.994. In this study male were 51.2% and female were 48.8%. About 40 (32% patients were anti HCV reactive. Conclusion: It is revealed that HCV infection significantly increased the risk of stroke.
Background: In chronic hepatitis diseases the liver impairment results in imbalance in glucose homeostasis and metabolism resulting in type 2 diabetes Aim: To estimate the frequency of type 2 diabetes in chronic hepatitis B and C patients. Study Design: Cross sectional analytical study Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana 1st October 2020 to 31st March 2021. Methodology: One hundred patients of hepatitis were recruited. Fifty patients of hepatitis B and 50 patients of hepatitis C age 20-65 years were enrolled. Their fasting blood sugar and HbA1C levels were analyzed and correlated with their clinical symptoms. Results: 20% hepatitis B and 26% hepatitis patients had asymptomatic type 2 diabetes. There were more men affected from hepatitis than women and type 2 diabetic respectively. Conclusion: Asymptomatic type 2 diabetics need suffering from hepatitis B and hepatitis C need to be screened for better treatment plan. Keyword: Hepatitis B, Hepatitis C, Type 2 diabetes
Aim: To assess the neurological and mental health responses to pandemic Covid-19. Study design: Cohort study Place and duration of study: Department of Medicine, Chandka Medical College Hospital Larkana and Department of Medicine, Khairpur Medical College Hospital Khairpur Mir’s from 1st October 2021 to 31st March 2022. Methodology: Two hundred patients who suffered Covid-19 infection and 200 who had any other life event except Covid-19 were enrolled. All patients who were above 18 years of age and were positive for Covid-19 through reverse transcriptase PCR were included in the study.Global Psych trauma Screening was done by enlisting twenty-two items which assessed trauma related symptoms while five items only assessed the factors increasing risks. Results: There were 112 (56%) females and 88 (44%) males in Covid-19 patients and 150 (75%) females and 50 (25%) males in non-Covid patients. The mean age of the Covid-19 patients was 49.65±15.5 year while of non Covid patients was 39.02±12.01 years. A significant increase in post-traumatic stress disorder (PTSD) cases probability was noted in the Covid-19 cases than non Covid-19 related events. Neurological responses showed that patients who had suffered from Covid 19 infections had a generalized weakness with hyposmia formation. Conclusion: Covid-19 is related with high level of depression, anxiety, hyposmia and other mental and neurological responses. Keywords: Neurological health, Mental health, Response, Covid-19
Objective: To determine the association of adverse outcomes in term of mortality in patients with cirrhosis presented with coronavirus disease. Study Design: Retrospective/observational study Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st March 2019 to 31st December 2020. Methodology: Two hundred and twenty covid-19 patients of both genders with or without chronic liver disease were enrolled in this study. Patients were categorized in to two groups. Group A (with cirrhosis 60 patients) and group B (without cirrhosis 60 patients). Outcomes in term of mortality between both groups were examined. Results: There were 38 (63.33%) males and 22 (36.67%) were females with mean age 46.14±8.44 years in group A while in group B, 40 (66.67%) and 20 (33.33%) patients were males and females with mean age 45.26±9.34 years. Patients with cirrhosis had high mortality rate as compared to patients without cirrhosis (33.33% Vs 13.33%) with p-value 0.0001. Conclusion: A significant association of adverse outcomes was found in cirrhotic patients with coronavirus disease. Keywords: Chronic Liver Disease, Corvid-19, Mortality
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