A new series of (s)-1- {3-[4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmetyl}-3-substituted-urea derivatives have been synthesized and characterized with spectral data, such as IR, NMR and Mass spectroscopies. All compounds are in vitro evaluated for their efficacy as antimicrobial agent against the gram-positive pathogenic strains such as Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228 and Streptococcus pyogens ATCC 8668. Five compounds (19k, 19l, 19m, 19n and 19o) out of 15 compounds showed moderate activity.
Literature survey revealed that the oxazolidinone derivatives exhibit pharmacological significance.
Thus, by targeting to design new antimicrobial agent, a novel series of oxazolidinone derivatives
(11a-t) having benzo[b]thiophene moiety were synthesized. Chemical structures of the synthesized
compounds were confirmed through spectroscopic techniques such as IR, NMR and Mass spectroscopy.
All the new synthesized compounds were subjected to in vitro antimicrobial testing by estimating
zone of inhibition toward Gram-positive pathogens like Bacillus subtilis ATCC 6633, Staphylococcus
aureus ATCC 25923 and Streptococcus pyogens ATCC 8668.
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