Rhodamine 6G – polymethylmethacrylate/polycarbonate (Rh6G–PMMA/PC) were prepared by a casting method at room temperature with diverse volume ratios of Rh6G dye solution (5, 10, 15, 20 and 25) ml. The as-prepared films were categorised via UV–Vis spectrophotometer, and the optical properties were investigated in the wavelength range of (200-800) nm. The absorption peaks for pure PMMA/PC film were affected by inserting Rh6G dye solution, the wavelength of absorption peak of pure PMMA/PC film is at 300 nm and 340 nm while there are different behaveior at different concentration of RG6 after mixing with PMMA/PC films; there are red shift for concentrations (10 and 25 ml) of RG6 after mixing with PMMA/PC films by appear another peaks at 530 nm and 535 nm respectively. In addition, there is a blue shift for concentrations (15 and 20 ml) of RG6 after mixing with PMMA/PC films, as evidenced by the appearance of new peaks at wavelength 265 nm. Furthermore, new peaks appeared and were absorbed while the energy band gap was influenced, with values ranging from 4.3 eV for pure PMMA/PC film to 4.18 eV for mixtures 10 and 25 ml concentration of Rh6G/ PMMA/PC belonging to the red shift to 4.9 eV and 4.85 eV for mixtures 15 and 20 ml concentration of Rh6G/ PMMA/PC belonging to the blue shift.
Hypertrophic scars are pathological scars which result from exaggerated skin proliferation following a wound and injury. Although many theories have been implicated for keloidogenesis, the precise pathophysiological cause is still masked. Different treatment strategies have been tried in their management, but there is no satisfactory option for treating hypertrophic scar currently; moreover the standard steroid therapy is associated with numerous local side effects, and there is a need for researches in new treatment options. The aim of this study is to evaluate the role of topical isoxsuprine in experimentally induced hypertrophic scar in rabbits. In the current experimental study, 40 healthy male albino rabbits between 12 and 14 months of age were studied. These rabbits were categorized into five groups: healthy animal group (n = 8), hypertrophic scar without treatment (n = 8), hypertrophic scar treated with triamcinolone acetonide gel (n = 8), and hypertrophic scar treated with isoxsuprine gel (n = 8). Histological assessment of skin biopsy, including the conventional hematoxylin and eosin stain, and immunohistochemistry for transforming the growth factor beta 1 level (TGF-β1) and collagen 3 alpha1 (COLIIIαI) in skin tissue was done. The immunohistochemical score of TGF-β and collagen III was highest in group 2 (hypertrophic scar without treatment), followed by group 3 (hypertrophic scar treated with triamcinolone acetonide gel) and group 4 (hypertrophic scar treated with isoxsuprine gel) -no significant difference between them since p > 0.05, and then by group 1 (healthy control group). Regarding histopathological scores of inflammation, the scar height, and scar index, the scores were highest in was highest in group 2 (hypertrophic scar without treatment), followed by group 3 (hypertrophic scar treated with triamcinolone acetonide gel) and group 4 (hypertrophic scar treated with isoxsuprine gel) -no significant difference between them since p > 0.05,
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