Background
Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects.
Methods
The intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze.
Results
One hour of epidural GES delivered over a month significantly (1) reduced Aβ load in the AD brain, (2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1 + cells, and (3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied.
Conclusion
The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provide guidance for the development of this promising therapeutic approach.
Background: Gamma electrical stimulation (GES) may reduce AD-specific pathology. Yet, the efficacy of electrical stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects.
Objective: The effect of GES on Aβ clearance and microglia modulation were assessed in 5xFAD mouse brain, as well as the behavioral performance of the animals in the Morris Water Maze.
Methods and Results: One hour of epidural GES at 40Hz delivered over a month significantly 1) reduced Aβ42 load in the AD brain, 2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1+ cells, and 3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied.
Conclusion: The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provides guidance for the development of this promising therapeutic approach.
Background: Gamma sensory stimulation may reduce AD-specific pathology. Yet, the efficacy of alternating electrical current stimulation in animal models of AD is unknown, and prior research has not addressed intensity-dependent effects.
Objective: The intensity-dependent effect of gamma electrical stimulation (GES) with a sinusoidal alternating current at 40 Hz on Aβ clearance and microglia modulation were assessed in 5xFAD mouse hippocampus and cortex, as well as the behavioral performance of the animals with the Morris Water Maze.
Methods and Results: One hour of epidural GES delivered over a month significantly 1) reduced Aβ42 load in the AD brain, 2) increased microglia cell counts, decreased cell body size, increased length of cellular processes of the Iba1+ cells, and 3) improved behavioral performance (learning & memory). All these effects were most pronounced when a higher stimulation current was applied.
Conclusion: The efficacy of GES on the reduction of AD pathology and the intensity-dependent feature provides guidance for the development of this promising therapeutic approach.
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