The Guanine-nucleotide binding protein 2 (GNB2) encodes for β2 subunit (Gβ2) of the G-protein complex. Keeping in view the increased demand of reliable biomarkers in cancer, the current study was planned to extensively explored GNB2 expression variation and its roles in different cancers using online available databases and diverse methodology. In view of our results, the GNB2 was notably up-regulated relative to corresponding controls in twenty three cancer types. As well, the elevated expression of GNB2 was found to be associated with the reduced overall survival (OS) of the Liver Hepatocellular Carcinoma (LIHC) and Rectum Adenocarcinoma (READ) only out of all analyzed cancer types. This implies GNB2 plays vital role in the tumorigenesis of LIHC and READ. Several additional analysis also explored six critical pathways and few important correlations related to GNB2 expression and different other parameters such as promoter methylation, tumor purity, CD8+ T immune cells infiltration, and genetic alteration, and chemotherapeutic drugs. In conclusion, GNB2 gene has been identified in this study as a shared potential biomarker (diagnostic and prognostic) of LIHC and READ.
The complex multiphase gas-solid flow has always been a point of attraction for researchers over the past decade to explore the sensing techniques to sense and measure the mass flow. Weather dilute or dense phase flow, the gas-solid flow measurement generally requires velocity profile and volumetric concentration measurement to find the mass flow rate. The nature of the solids, the environmental factors-specially moisture adversely affects the sensor readings-specifically when it is non-invasive capacitive sensors. Gas-solid flow finds its applications in power plants, food, chemical, automobile, and pharmaceutical industries. This paper aims to explore the evolution of a novel approach of using load cell in conjunction with capacitive electrodes for calculating the mass flow rate of the solids.
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