Background: A recent standardized therapeutic technique for the patients having advanced and large (bigger than two centimeters) breast cancer is neo-adjuvant chemotherapy. The gold standard is the histo-pathological assessment of carcinoma response. Methodology: In this research study, we performed the histo-pathologic evaluation of forty-four samples received in the pathology department over a period of one year from 1 July 2021 to 30 June 2022. Results: In this research study, we studied total forty-four patients with breast cancer. Average age of these females was fifty years. Average size prior CT was 56.140 centimeter square and post CT was 29.4 centimeter square. In this research work, complete pathologic response was shown by eighteen percent patients and incomplete response was shown by eighty-four percent patients. Conclusion: Changes in pattern of characterizations examined after the histo-pathological evaluation of tumor are dystrophic calcification, stromal hyalinization, regions of coagulated necrosis, reactive infiltration of lymphocytes, cellular fibrous tissue and hemosiderin laden macrophages. Keywords: Characterization, pathology, evaluation, neo-adjuvant chemotherapy, carcinoma, cancer, average.
An insecticide containing the neonicotinoid thiamethoxam + the diamide chlorantraniliprole was evaluated against adults of Rhyzopertha dominica, Tribolium castaneum, Trogoderma granarium, and Sitophilus oryzae under laboratory bioassays both on freshly treated grain as well as on treated grain stored over 90 days for its persistence in efficacy. In laboratory bioassays, the insecticide was applied on wheat, maize, or rice at four doses, while in persistence bioassays on wheat at the same doses. Mortality and progeny were assessed in both laboratory and persistence bioassays. After 14 days of exposure, S. oryzae exhibited 100% mortality on all three commodities at the highest dose, while R. dominica showed complete mortality on wheat or rice and T. castaneum on wheat. For a period of 90 days, S. oryzae exhibited 42.69% mortality, followed by R. dominica (35.26%), T. castaneum (27.08%), and T. granarium (18.63%) at the highest dose. Progeny was successfully suppressed in all cases of complete mortality in laboratory bioassays and for S. oryzae for 90 days in persistence bioassays. Laboratory trials were also performed on plywood, concrete, ceramic tile, and steel at one dose. The highest mortality was observed on steel, followed by concrete, ceramic tile, and plywood for all insect species tested. This study demonstrates that thiamethoxam + chlorantraniliprole is effective against the tested species depending on exposure, storage period, surface, commodity, and dose.
A good quality fruit fetches a high market value. Citrus canker disease badly affects quality of citrus fruits including grapefruit. The present study was conducted to find out suitable chemicals, alone or incombination, for the control of citrus canker. The experiment was conducted on 15-year-old disease-affected grapefruit cv. Shamber plants in the orchard of Horticultural Research Station, Sahiwal to control the disease for better quality fruit production. Therefore, four sprays of Aliette (300 g 100 L-1 of water), Bordeaux mixture (1:1:100), Flare (100 g 100 L-1 of water) or Bordeaux mixture + Flare were applied; two in the month of March and other two in the month of August with fifteen days interval along with control (no chemical). Combined application of Bordeaux mixture and Flare reduced the attack of citrus canker on leaves and fruits. Comparatively lower values of affected leaves (1.27%), lesions per leaf (0.40), affected fruits (0.25 %) and lesions per fruit (0.22) were observed in the treatment in which a combination of Bordeaux mixture and Flare was sprayed on the plants. The disease percentage was high on leaves and fruits of unsprayed (control) plants, while other thee treatment were in the middle in their efficacy to control the disease.
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