Raynaud's phenomenon (RP) is a multifactorial vasospastic disorder characterized by a transient, recurrent, and reversible constriction of peripheral blood vessels. RP is documented to affect up to 5% of the general population, but variation in its prevalence is commonly recognized owing to many factors, including varied definitions, gender, genetics, hormones, and region. Furthermore, RP may be idiopathic or be a clinical manifestation of an underlying illness. Patients with RP classically describe a triphasic discoloration of the affected area, beginning with pallor, followed by cyanosis, and finally ending with erythema. This change in color spares the thumb and is often associated with pain. Each attack may persist from several minutes to hours.Moreover, the transient cessation of blood flow in RP is postulated to be mediated by neural and vascular mechanisms. Both structural and functional alterations observed in the blood vessels contribute to the vascular abnormalities documented in RP. However, functional impairment serves as a primary contributor to the pathophysiology of primary Raynaud's. Substances like endothelin-1, angiotensin, and angiopoietin-2 play a significant role in the vessel-mediated pathophysiology of RP. The role of nitric oxide in the development of this phenomenon is still complex. Neural abnormalities resulting in RP are recognized as either being concerned with central mechanisms or peripheral mechanisms. CNS involvement in RP may be suggested by the fact that emotional distress and low temperature serve as major triggers for an attack, but recent observations have highlighted the importance of locally produced factors in this regard as well. Impaired vasodilation, increased vasoconstriction, and several intravascular abnormalities have been documented as potential contributors to the development of this disorder. RP has also been observed to occur as a side effect of various drugs.Recent advances in understanding the mechanism of RP have yielded better pharmacological therapies. However, general lifestyle modifications along with other nonpharmacological interventions remain first-line in the management of these patients. Calcium channel blockers, alpha-1 adrenoreceptor antagonists, angiotensin-converting enzyme inhibitors, nitric oxide, prostaglandin analogs, and phosphodiesterase inhibitors are some of the common classes of drugs that have been found to be therapeutically significant in the management of RP. Additionally, anxiety management, measures to avoid colder temperatures, and smoking cessation, along with other simple modifications, have proven to be effective non-drug strategies in patients experiencing milder symptoms.
Gender disparity is pervasive and persisting in research. Despite gender being recognized as one of the primary determinants of health, inadequate representation of women in clinical trials has resulted in a deficit pertaining to equity in health care. This gross underrepresentation has exposed women to unforeseen health‐related outcomes, and as evident through historic records, unequal distribution of opportunities has further widened this gender gap in health care.
Diversity, equity, and inclusion (DEI) are core values that are unequivocally essential to healthcare research and practice. However, global health inequities remain pervasive and disruptive to the delivery of healthcare. This unacceptable lack of inclusivity and equity infiltrates all aspects of medicine, including research and publication. Accordingly, there is a dissemination of unbalanced and homogenous perspectives which are not representative of the global population. The International Journal of Medical Students (IJMS) has strived to counter such biases through the development of content and the process of its publication. Further, the selection of its editorial team and ambassadors is conducted with the intention of diversity. We respect individual differences and celebrate them as strengths adding to the quality of our journal. Therefore, the IJMS has taken a positive step toward an equitable environment by publishing a policy statement on DEI. We hope to lead by example by fostering a culture of inclusivity for all researchers, regardless of background. Though, we recognize the complexity of implementing comprehensive DEI practices and consider it our duty to the community that we continuously develop through a dedicated effort and iterative process.
The only constant in our lives is change. However, daring to make a change is another matter. There is a degree of apprehension regarding inconstancy in our general population and even more so in the medical community. The International Journal of Medical Students (IJMS) calls for overcoming this inertia and is leading the way for improved global healthcare. [1][2][3][4][5][6][7] This issue brings to light how, across the world, we are seeing examples of change and how this is improving our understanding of the human body and the world. We explore first-hand experiences of mitigating COVID-19 while also keeping in touch with other areas of clinical medicine and scientific research. We also take a look at concerns surrounding environmental healthcare and simultaneously, urge all readers to engage in the cause with us. Core to the IJMS in leading as a changemaker is through initiating empowerment, building a strategy, and utilizing our resources and the skills of all medical students across the globe to facilitate change into a reality.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.