We show existence and uniqueness of solutions to an initial boundary value problem that entails a pantograph type functional partial differential equation with two advanced nonlocal terms. The problem models cell growth and division into two daughter cells of different sizes. There is a paucity of information about the solution to the problem for an arbitrary initial cell distribution.
We show existence and uniqueness of solutions to an initial boundary value problem that entails a pantograph type functional partial differential equation with two advanced nonlocal terms. The problem models cell growth and division into two daughter cells of different sizes. There is a paucity of information about the solution to the problem for an arbitrary initial cell distribution.
doi:10.1017/S144618112100002X
In this paper, we study initial boundary value problems that involve functional (nonlocal) partial differential equations with variable coefficients. These problems arise in cell growth models with symmetric and asymmetric modes of division. We determine the general solution to the symmetric cell division problem for a certain class of coefficients and establish the convergence of solutions to a large time asymptotic solution. The existence of a steady size distribution (SSD) solution for an asymmetric cell division problem is established and is shown to be the large time-attracting solution for a certain class of coefficients. The rate of convergence of solutions towards the SSD solution is affected by the choice of coefficients and remains unaffected by the asymmetry in cell division. The uniqueness of solutions to the initial boundary value problem is also established.
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