Synthetic food colorants are widely added to food in order to attract the consumer. Many researchers have incriminated these additives for causing some problems to human health. This research was conducted to determinate the toxic effects of some selected synthetic food dyes (A, B and C) in some biochemical parameters of male albino rats in the acute test. The limit test dose of 5000 mg/kg was administered to four albino rats and then observed individually 1hour post-dosing, and at least once daily for 14 days. Sub-chronic toxicity was evaluated after administering daily oral doses of 1000, 2000, 3000 and 4000 mg/kg body weight, for 28 days to the albino rats. Results of the acute toxicity study indicated that the LD50 of the three different standard synthetic color additives (A), (B) and (C) is more than 5000 mg/kg. While in sub-chronic toxicity studies administration of synthetic food colorants, showed significant increases (P<0.05), in aspartate amino-transferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum urea (SUR) and serum creatinine (SCR) values of rats treated with synthetic dyes when compared to those of the control group. The study showed that it takes more than 5000 mg/kg dose of the dye to kill the tested albino rats and also indicated that the colorants affect the liver and kidney functions
Co (II), Ni (II) and V (III) metal complexes were synthesized mechanochemically using L-Leucine, L-Tyrosine and Creatinine as mixed ligands. The metals and the ligands were grounded using an agate mortar with a pestle. The compounds formed were characterized using their melting/decomposition temperature, solubility, magnetic susceptibility, conductivity measurement, Infrared analysis and scanning electron microscope (SEM). The Metal – ligand ratios were investigated via Job’s method of continuous variation. The shifts of bands (for instance 1693-1677 cm-1 to 1674-1607 cm-1) in C=O and the appearance of new bands in the complexes (683-669 and 713-750 cm-1 indicates the complexation. The lower conductivity measurement values (15.00 to 32.40) µS.cm-1 suggested the non-electrolytic nature of the complexes. The magnetic effective value of the metal complexes showed that all the three complexes are paramagnetic and octahedral. It was concluded that the amino acids (ligands) coordinated in a bidentate way through the nitrogen from the amino group and oxygen from carboxylate. The complexes were screened for their antimicrobial activities against two bacterial isolates (Streptococcus pneumoniae and Klebsiella pneumoniae). All the complexes exhibited good activity against the organisms
Plant extracts are most of the time used for antioxidant and antimicrobial studies. The Present study was designed to evaluate the activity of metal complexes as antioxidant and against some selected bacterial and fungal isolates. The new metal complexes of Cr (III) and Zn (II) containing ligands derived from Tyrosine, Leucine and 2 – imino – 1 – methylimidazolidin – 4 - one were selected. The test compounds were evaluated for their possible antioxidant activity through free radical scavenging activity via using 1,1 – diphenyl – 2 – picryl – hydrazyl (DPPH) method. All the complexes exhibited good to moderate activity with Cr (III) complex (CrL1) and (CrL2) as the best radical scavengers having the % inhibition value of 67.74 and 65.33 respectively. The complexes were also screened for their antimicrobial activities against two bacterial isolates and one fungal isolate (Streptococcus pneumoniae, Klebsiella pneumoniae and Aspergillus niger). The result showed that all the compounds have the moderate activity against the tested organisms.
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