Three-dimensional (3D) bio-printing has been shown up as a state of the art and creative technological solution to nowadays tissue engineering and stem cell research challenges toward human tissue regeneration and construction of artificial living organs. Thereby, using hydrogel-based bio-inks to 3D print living microenvironments is a crucial strategy to reconstruct basically functional living scaffolds in order to shape human living organs based on digital 3D computer-aided design (CAD) inputs. The focus of this paper lies on design and development of a portable multi-functional 3D bio-printing extruder for fabrication of hydrogel-based highly complex living tissues using advanced methods invented along this study. The presented article, precisely optimizes the process of fabricating 3D printed scaffolds by redesigning of an integrated gel-extrusion system capable of controlling the adjustability of thermal condition of bio-inks. Also a UV crosslink module is utilized in the bottom of the extruder to cure hydrogel scaffolds consisting of photo-reacting agents to provide a novel bio-printing experience for end users. As a result, the integrated extrusion system is easily portable and compatible with almost any computer numerical control (CNC) machine. Therefore, it could be simply installed on or removed from any CNC machine or fused deposition modeling (FDM) 3D printing system considering that all the control units remain adjustable. The whole system parameters and the performance of tissue fabrication regarding this developed portable multi-functional 3D bio-printing extruder have been tested and practically confirmed. The thermal control system performance has also been simulated using finite element analysis (FEA) and computational fluid dynamics (CFD) methods. Thus, certified documents have been provided and depicted in this paper.
For optical fibre sensors applications, nanomaterials have been widely used to enhance sensor performance. Here, the fibre optic uses the transmission of light by total internal reflection along with the fibre and depending on the diameter of the fibre and the wavelength of the light used. Among others, graphene oxides nanostructures (GO) would offer exceptional advantages on the sensing mechanism due to 2D properties of the monocellular layer originally from graphite. The main objectives of this research are to successfully synthesis of GO using a chemical reduction method known as modifies Hummer’s method and later, deposited the GO onto the modified fibre optic layer to create a sensing platform. Prior than that, the standard plastic of fibre optic (POF) was modified by removing the cladding layer (1 cm) using a mechanical etching technique, thus the sensing platform can be created. The morphology and optical properties of the system were characterised using scanning electron microscopy (SEM) and ultraviolet-visible (UV-Vis) spectroscopy. Result of the preparation and characterisation of GO-optical fibre coatings was presented, considering its potential use for sensing applications. The stable GO was prepared by 3 hours of stirring time during the synthesis and longer dipping time was preferred to fully coat the core of the exposed POF. Aiming to explore this scheme for sensing applications, GO-coated tilted fibre will be later measuring via refractive index variations. An improvement on the sensitivity should be obtained and thus become a promising sensing platform for the development of a new line of sensors.
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