An ultrathin single-layer metasurface manifesting both linear cross-polarization conversion (CPC) and linear-to-circular polarization (LP-to-CP) conversion in X-band is presented in this research. The designed metasurface acts as a multifunctional metasurface achieving CPC over a fractional bandwidth of 31.6% (8–11 GHz) with more than 95% efficiency while linear-to-circular polarization conversion is realized over two frequency bands from 7.5–7.7 GHz and 11.5–11.9 GHz. Moreover, the overall optimized structure of the unit cell results in a stable polarization transformation against changes in the incidence angle up to 45° both for transverse-electric (TE) and transverse-magnetic (TM) polarizations. The proposed metasurface with simple structure, compact size, angular stability and multifunctional capability qualifies for many applications in communication and polarization manipulating devices.
Defects in autophagy are implicated in a growing number of diseases. Jelani
et al.
identify a mutation in
WIPI2
, a major autophagy gene, associated with a multisystemic global developmental disorder. Functional studies in cell lines derived from patients reveal significant reductions in the classic hallmarks of autophagy.
Abnormal post-transcriptional modulations in inflammatory genes by microRNAs (miRNAs) play a crucial role in human disorders including arthritis. In this study, we determined the effect of hsa-miR-125b-5p on interleukin (IL)-1β induced inflammatory genes in human osteoarthritic (OA) chondrocytes. Bioinformatics algorithms showed 3′untranslated region (3′UTR) of TRAF6 mRNA (NM_004620.3) has perfectly matched ‘seed-sequence’ for hsa-miR-125b-5p. Treatment of cells with IL-1β up-regulates TRAF6 mRNA and down-regulates hsa-miR-125b-5p expression. This negative correlation between TRAF6 and hsa-miR-125b-5p was verified by transfection with miR-125b mimic (pre-miR-125b). Moreover, transfection with miR-125b mimic caused marked inhibition of IL-1β-induced phosphorylation of p38-MAPK, JNK-MAPKs and ERK-MAPKs and also suppressed the nuclear levels of NF-κBp50, NF-κBp65 and inhibited the activation of IκBα. Furthermore, transfected chondrocytes with miR-125b mimic in the presence of IL-1β also showed marked inhibition in the secretion of several proinflammatory cytokines, chemokines and growth factors including IL-6, IL-8, INF-γ, TGF-β1, IGFBP-1 and PGDF-BB. Importantly, this transfection also significantly inhibited IL-1β- induced MMP-13 expression/production. In short, this study concludes that hsa-miR-125b-5p acts as a negative co-regulator of inflammatory genes including MMP-13 via targeting TRAF6/MAPKs/NF-κB pathway in human OA chondrocytes.
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