Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidant that has shown to posses anticancer, antioxidant and anti-inflammatory properties. However, the poor solubility leads to poor bioavailability and limits its development.The aim of the research is to investigate the effect of fisetin nanosuspension using a nanoprecipitation technique and additional stabilizers polysorbat 80, SLS, PVA and Eudragit on particle size average, polydispersity index and zeta potential.The suspensions of microcrystalline FIS were prepared by a nanoprecipitation technique with different proportion of stabilizers fixed. The nanosuspension produced was then characterized using Photon Correlation Spectroscopy (PCS) in term of particle size distribution, polydispersity index, zeta potential and morphology nanosuspensiom (TEM). Result showed fisetin nanosuspension were successfully prepared by anti-solvent precipitation with additional stabilizer SLS and polysorbat 80. The nanosuspension containing polysorbat 80 showed smaller average particle size of 225.7 nm ± 1.31, a polydispersity index of 0.272 ±0.02 and zeta potential -39.3 ± 0.26 was obtained. Conclusion, FIS nanosuspension successfully prepared by nanoprecipitation tecnique with the polysorbate 80 as stabilizer and ethanol as solvent were spherical in shape..
Pendahuluan : Morin (3,5,7, 2,4’- pentahidroksiflavone) adalah senyawa flavonoid golongan flavonol yang poten sebagai antioksidan, antikanker, antiinflamasi dan sebagai antidiabetes. Morin bersifat lipofil, tidak larut dalam air sehingga ketersediaan hayati dan aplikasi klinis menjadi terbatas. Nanosuspensi adalah sistem dispersi koloidal, 100% mengandung bahan obat dengan ukuran 10-1000 nm, tidak mengandung bahan pembawa apapun kecuali sebagai bahan penstabil. Tujuan : Penelitian ini bertujuan membuat nanosuspensi morin yang stabil dengan metode sonopresipitasi. Karakterisasi nanosuspensi meliputi ukuran partikel, indeks polidispersitas, zeta potensial, morfologi nanosuspensi dan aktivitas antioksidan. Metode : Nanosuspensi morin dibuat dengan metode sonopresipitasi dengan frekuensi 50 kHz selama 8 menit dengan variasi bahan penstabil jenis surfaktan, polimer dan kombinasi keduanya. Karakterisasi nanosuspensi meliputi ukuran partikel, indeks polidispersitas, zeta potensial, morfologi partikel (TEM), stabilitas fisik dan aktivitas antioksidan. Kesimpulan : Morin berhasil dikembangkan menjadi nanosuspensi dengan metode sonopresipitasi. Formula 7 dengan stabilizer SLS-Pluronic F68 (0,5:1) merupakan formula terpilih dengan ukuran partikel terkecil sebesar 182,7 nm, ukuran partikel seragam (PI : 0,210), stabil setelah penyimpanan 8 minggu dengan nilai zeta potensial -37,8 mV. Aktivitas antioksidan nanosuspensi morin meningkat sebesar 2-3 kali
Background: Phytosomes are recently introduced drug delivery system and novel botanical formulation to produce lipophilic molecular complex to improve absorption and bioavailability of phytoconstituent. Myricetin is a well-known flavonoid with different biological effects and contributed in food preserving by free radical scavenging activity. However, bioavailability of myricetin is an important limiting factor for its antioxidant activities. Purpose: To overcome this limitation, in the present study we aimed to produce myricetin-loaded nano phytosomes to improve its physicochemical stability and bioavailability. Methods: myricetin-loaded nano phytosome was prepared by using phosphatidylcholine (PC) and cholesterol (CH). Myricetin nanophytosomes system was characterized by particle size analyzer, particle size distribution (PDI), encapsulation efficiency and potential antioxidant activity. Results: Results showed that formulation with the myricetin: PC: CH molar ratio of 1: 2: 0.8 had lower particle size (291.11 nm) and higher encapsulation efficiency percent (93%). Morphology analysis showed that myricetin nanophytosome spherical shape. The potential antioxidant data showed that incorporation myricetin in the phospholipid myricetin remained unchanged even after encapsulation of myricetin in binarynanophytosome formulation. Conclusion: Nano phytosomal formulation of myricetin showed promising potential in fortification of nutraceutical with water insoluble antioxidants.
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