Consanguineous marriage is a union between first or second cousins. This practice is very common in developing Asian countries especially Pakistan. Around 70% of marriages in Pakistan are consanguineous. The major factors that promote consanguinity are arranged marriages, illiteracy and inter-caste marriages. The complications that follow include, small birth size, congenital malformations, neonatal mortality, rare genetic disorders, congenital deafness, congenital heart disorders and mental retardation. Serious steps must be taken to overcome this ongoing crises. Counselling, genetic screening, pre-natal diagnostic tests are some of the measures that are essential. Government involvement is also necessary to promote awareness and discourage consanguinity.
Acute bacterial meningitis is one of the very common and severe forms of central nervous system (CNS) infection worldwide in almost all age groups. It remains a common cause of mortality, especially in underdeveloped countries, if not treated timely. Detecting an organism from the CSF culture is crucial in the management of acute bacterial meningitis. Selection of antibiotics according to the culture are a very important part of the management. Most commonly involved organisms include Streptococcus pneumoniae, Neisseria meningitides, and Listeria monocytogenes, while other organisms are very uncommon. Here, we report a rare case of Klebsiella pneumoniae meningitis in a young female, which was found resistant to multiple antibiotics including third generation of cephalosporin.
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