Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis is the most dangerous infectious disease in the world. The purpose of this study was to determine the level of antibiotic resistance to rofampicin on positive TB results in the Mataram City Hospital. In this research, the research method used is analytic observational. The research data used is in the form of secondary data, which comes from the tuberculosis examination report book. In this study, the research sample was 290 samples during the January-December 2019 examination period at the Mataram City Hospital. The results indicated that at the Mataram City Hospital, there were 11 samples (4%) that were not resistant to the antibiotic rifampin and 275 samples (95%) were still sensitive and 4 other samples (1%) could not be determined to the antibiotic.
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