Arylsulfonyl compounds are among the most important compounds in pharmaceutical and medicinal chemistry. Hence, a wide variety of sulfonylation methods have been reported recently. This review summarizes arylsulfonylation methodologies developed in the last 5 years and includes two major categories. The first entails direct arylsulfonylation and the second multicomponent arylsulfonylation. In direct arylsulfonylation, arylsulfonyl reagents react with C−H activated compounds, alkynes, and alkenes through coupling or addition reactions. In multicomponent reactions, arylation reagents and various substrates react with sulfur dioxide surrogates, such as DABSO, Na 2 S 2 O 5 , and K 2 S 2 O 5 . Arylsulfonyl hydrazides, aryl boronic acids, aryl silanes, and aryl halides are the most widely employed arylation reagents that react with sulfur dioxide surrogates to generate an arylsulfonyl source, and ensuing reactions proceed via pathways analogous to those of direct arylsulfonylation.

N-Acylglutarimides and arylsiloxanes reacted in the presence of Pd­(OAc)2/PCy3, Et3N·3HF, and LiOAc to provide the corresponding arylketones in good yields. Aryl-, vinyl-, and alkyl-substituted N-acylglutarimides showed good activity in the coupling reactions of arylsiloxanes. The reaction had a broad substrate scope and showed good functional group tolerance. N-Benzoylsuccinimide and N-protected N-phenylbenzamides showed good activities in coupling reactions with phenylsiloxane. The employment of CuF2 as an activor afforded the decarbonylative products at 160 °C.

The C-N bond of tertiary amines was activated in the presence of a palladium catalyst and peroxide and subsequently reacted with tertiary amides to provide transamidated products in good yields....