Polyether Ether Ketone (PEEK) is a biocompatible alternative to metallic biomaterials because of its unique properties such as relatively low elastic modulus, high mechanical strength, and biocompatibility. A signi cant issue is that its bioinert feature might lead to implant failure due to poor osseointegration.Therefore, this research aims to develop the nSiO 2 ceramic particles reinforced PEEK (nSiO 2 @PEEK) polymer nanocomposite. The particle size of nanoparticles was measured as 43.6 nm using particle size analyzer (PSA). The fabrication was done by the vertical injection moulding process. The morphology of fabricated composite was analyzed using FESEM. The EDAX and elemental mapping revealed the presence of Si, C, and O elements in nSiO 2 @PEEK. The structural characteristic of nSiO 2 @PEEK nanocomposite was investigated using XRD and FTIR. Thermal stability and melting behavior were examined using TGA thermograms and DSC curves. Minimum toxic level (Grade: slight, 1-20%) was observed by in-vitro cytotoxicity assessment using direct and indirect methods. The excellent cell viability was found as 83.6% through MTT assay. The MG-63 cell-adhesion study was conducted subsequently excellent cell growth and cell-morphology were monitored using SEM analysis. Thereby, the developed nanocomposite was found to be good biocompatible properties through this research. Thus it can be suitable as promising biomaterial for medical implant applications.
This paper presents the formulation, characterization, and in vitro studies of polymer composite material impregnated with naturally derived hydroxyapatite (HA) particulates for biomedical implant applications. Laevistrombus canarium (LC) seashells (SS) were collected, washed and cleaned, sun-dried for 24 h, and ground into powder particulates. The SS particulates of different weight percentages (0, 10, 20, 30, 40, 50 wt%)-loaded high-density polyethylene (HDPE) composites were fabricated by compression molding for comparative in vitro assessment. A temperature-controlled compression molding technique was used with the operating pressure of 2 to 3 bars for particulate retention in the HDPE matrix during molding. The HDPE/LC composite was fabricated and characterized using X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM), energy-dispersive X-ray (EDX), differential scanning calorimetry (DSC), and TGA. Mechanical properties such as tensile, compression, flexural, hardness, and also surface roughness were tested as per ASTM standards. Mass degradation and thermal stability of the HDPE/LC composite were evaluated at different temperatures ranging from 10 to 700 °C using thermogravimetric analysis (TGA). The maximum tensile strength was found to be 27 ± 0.5 MPa for 30 wt% HDPE/LC composite. The thermal energy absorbed during endothermic processes was recorded as 71.24 J/g and the peak melting temperature (Tm) was found to be 128.4 °C for the same 30 wt% of HDPE/LC composite specimen. Excellent cell viability was observed during the in vitro biocompatibility study for EtO-sterilized 30 wt% of HDPE/LC composite specimen, except for a report of mild cytotoxicity in the case of higher concentration (50 µL) of the MG-63 cell line. The results demonstrate the potential of the fabricated composite as a suitable biomaterial for medical implant applications.
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