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1. This study was conducted to determine the effects of hempseed (HS) on performance, egg traits, serum lipid profile and antioxidant activity in Japanese quail (Coturnix coturnix japonica). 2. A total of 120 eight-week-old laying quail were divided into 4 experimental groups with 10 replicates. The treatments were as follows: (1) control diet (C, no HS in the diet); (2) 5% HS in the diet (HS5); (3) 10% HS in the diet (HS10); and (4) 20% HS in the diet (HS20). The quail were fed the experimental diets from 8 to 14 weeks of age. 3. There was no significant difference in body weight, feed intake and feed conversion ratio of the birds overall in the experiment. The egg production was not influenced by the HS contents in the diet; however the HS10 diet increased egg weight and egg-specific gravity. The carcass traits were not affected by the HS contents. 4. The serum triglyceride, cholesterol and the high density lipoprotein were not significantly altered; however, low density lipoprotein (LDL) concentration in HS-supplemented groups were lower than that of the C group. 5. The malondialdehyde, superoxide dismutase, catalase and nitrogen oxide concentrations were not significantly affected, but in the HS10 and HS20, glutathione peroxidase (GSH-Px) concentration was higher than in the C and HS5 groups. 6. The omega-3 fatty acid content of eggs increased linearly with increasing dietary HS content in the diet. 7. In conclusion, HS could be a potential feed and health benefit as a natural antioxidant in relation to decreasing serum LDL and increasing GSH-Px concentration in the liver of laying quail.

In this study*, it was aimed to observe, genotoxic effects of antituberculosis drugs and combinations on rats. Animals were treated with 31.5 mg/kg isoniazid (INH), 54 mg/kg rifampicin (RIF), 189 mg/kg pyrazinamide (PYR), 100 mg/kg etham-butol(ETA), INH+RIF+PYR (MIX1) and INH+RIF+PYR+ETA (MIX2) mixtures applied via gavage for 90 days. At the end of the study, blood, liver and kidney samples were taken and evaluated by Comet and Micronucleus techniques. Compared to control group, head intensity decreased, tail intensity and tail migration increased on experiment groups in blood samples. Head intensity of PYR and mixture groups decreased, tail intensity of PYR and mixture groups increased and tail migration of PYR, ETA and mixture groups increased in liver samples. Head intensity decreased and tail intensity increased of INH, RIF, ETA and MIX1 group; tail migration increased of MIX1 group in kidney samples. Compared to control group, micronucleus rate of ETA, RIF and MIX 2 groups increased in experiment groups. In conclusion antituberculosis drugs and their mixtures applied for 90 days causes to double strand break of DNA damage at different degrees in blood, kidney and liver cells in rats.