An easy and convenient method is reported for the synthesis of 2-hydroxybenzaldehyde and 2-hydroxynaphthalene-1-carbaldehyde from corresponding phenols by Reimer-Tiemann reaction using aqueous ethyl alcohol and avoiding steam/vaccum distillation.
Some new 2,3-diaryl-1,3-thiazolidin-4-one derivatives having a 2,6-dichlorophenyl, antipyrine, or 1,2,4-triazole ring at N-3 and variously substituted 3-iodo-or 3-bromo-phenyl rings at C-2 have been synthesized and tested as antibacterial agents. The results of the in vitro tests showed that some of them have effective antibacterial activity.
Direct iodination of several reactive aromatic compounds like hydroxy substituted acetophenones and aldehydes with pyridinium iodochloride (PyICl) proceeded smoothly to afford the corresponding aromatic iodides in good to excellent yield. Pyridinium iodochloride has been found to be an efficient solid iodinating reagent with no hazardous effect and it can be handled safely.
Aldehydes Q 0320Synthesis of Substituted 2-Hydroxyaryl Aldehydes by the Microwave-Induced Reimer-Tiemann Reaction. -A very simple, fast, and general procedure for the formylation of substituted phenols is described. -(VIBHUTE*, Y. B.; LONKAR, S. M.; SAYYED, M. A.; BASEER, M. A.; Mendeleev Commun. 17 (2007) 1, 51; Dep. Chem., Yeshwant Coll., Nanded 431 602, India; Eng.) -H. Toeppel 34-077
Amines Q 0120 Convenient and Efficient Method for the Iodination of Aromatic Amines by Pyridinium Iodochloride. -The iodination occurs regioselectively directed by inductive and mesomeric effects. -(KHANSOLE, S. V.; JUNNE, S. B.; SAYYED, M. A.; VIBHUTE*, Y. B.; Synth.
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