MDR-MTB strains of the Beijing genotype might be spreading in Myanmar and present a major challenge to TB control in this country.

25The number of multi-drug-resistant tuberculosis (MDR-TB) cases is rising worldwide. As a 26 countermeasure against this situation, the implementation of rapid molecular tests to identify MDR-27 TB would be effective. To develop such tests, information on the frequency and distribution of

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Purpose: This study aimed to conduct Human Papillomavirus (HPV) DNA testing based cervical cancer screening among married women in Bogalay Township, Ayeyarwady Region, Myanmar and to triage with CINtec PLUS Cytology test among women who have HPV infection. Methods: It was a prospective cross-sectional descriptive study. Total of asymptomatic 677 married women (median age-40-years;range 30-55) residing in Bogalay Township, Ayeyarwady Region, Myanmar were screened in 2020. HPV-DNA testing was performed using cobas HPV-DNA-test which detects 14-high-risk-HPV genotypes -16,-18,-31,-33,-35,-39,-45,-51,-52,-56,-58,-59,-66 and-68. Positive HPV cases were followed by liquid-based- cytology (LBC) and CINtec PLUS Cytology i.e, dual-immuno-biomarker technology to simultaneously detect p-16 and Ki-67 to provide a strong indicator of the presence of transforming HPV infections. Results: HPV was identified in 4.6% (31/677) of screened women in Bogalay Township, Ayeyarwady Region, Myanmar. Among HPV-positive-cases, HPV-16 was 22.6 % (7/31), HPV-18 was 6.5% (2/31) and other-HR-HPV-genotypes (HPV-31,-33,-35,-39,-51,-52,-56,-58,-59,-66and-68) were 70.9% (22/31). In cytological-diagnosis of HPV positive women, 87.1% had cervical cytological abnormalities comprising; 16.1% had high grade squamous intraepithelial lesion (HSIL), 48.4% had low grade squamous intraepithelial lesion (LSIL) and 22.6% had atypical squamous cells of undetermined significance (ASCUS). Only 12.9% were negative for intraepithelial lesion or malignancy (NILM). In CINtec-PLUS-Cytology, all HSIL (100%) cases, 66.7% of LSIL, 14.3% of ASCUS were positive with both p-16 and Ki-67 dual-immuno-biomarker but negative in NILM cases. Conclusion: This study highlighted that using HPV-DNA test in cervical cancer screening, the highest risk women can be determined. In triage with CINtec-PLUS-Cytology in HPV positive women, women who were more significantly at risk for cervical pre-cancer and cancer as well as women that require referral to colposcopy were identified. In LSIL and ASCUS cases, CINtec-PLUS-Cytology may reduce the number of women that require referral to colposcopy. This study pointed out CINtec-PLUS-Cytology was very useful to confirm the high-grade cervical lesions. Citation Format: Mu Mu Shwe, Khin Kay Thwe, Su Su Hlaing, Lynn Pa Pa Aye, Kham Mo Aung, Nu Lwin, Win Maw Tun, Zaw Than Htun. Human Papillomavirus (HPV) DNA Testing Based Cervical Cancer Screening and Triage with CINtec PLUS Cytology Test in HPV Positive Women in Bogalay Township, Ayeyarwady Region, Myanmar [abstract]. In: Proceedings of the 9th Annual Symposium on Global Cancer Research; Global Cancer Research and Control: Looking Back and Charting a Path Forward; 2021 Mar 10-11. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2021;30(7 Suppl):Abstract nr 39.