Parthenium hysterophorus L., when fed to buffalo bull calves and cross bred bull calves resulted in acute toxicity leading to death. The former animals developed severe dermatitis. Autopsy revealed ulceration of alimentary tract. Extensive pathological changes were noticed in liver, kidney and skin.
We describe continuous venovenous hemodiafiltration (CVVHD) with a high-flux membrane as a novel treatment modality for vancomycin overdose associated with renal insufficiency. CVVHD was used in a 6-day-old male with a solitary hypodysplastic kidney, suspected sepsis, and anuric renal failure who subsequently received an accidental tenfold overdose of vancomycin. We furthermore present evidence for the importance of countercurrent dialysis in addition to continuous hemofiltration for optimal vancomycin removal.
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