Background: Cardiovascular (CV) morbidity is a major problem in patients suffering from depression as greater CV mortality is found in cardiac patients with depression. Objective: To assess cardiac autonomic nerve activity by power spectral analysis of heart rate variability in patients with Major Depressive disorder. Methods: This case control study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka during 2011. Sixty patients of both sexes with Major Depressive disorder (MDD) aged 20-50 years were enrolled. The patients were selected from the Department of Psychiatry in Bangabandhu Sheik Mujib Medical University (BSMMU). Thirty drug naive MDD patients and thirty medicated MDD patients were compared with 30 healthy control and also between them. The HRV parameters were recorded by 4 active channels, RMS Polyrite-D. For statistical analysis independent sample t-test test was used. Results: LF norm and LF/HF were significantly higher and Total power, HF power, HF norm were significantly lower in both drug naive and medicated MDD patients in comparison with those of healthy control. Conclusion: Autonomic nerve dysfunction involved both the drug naive and medicated MDD patients which was associated with higher sympathetic activity and reduced vagal modulation of the heart and sympathovagal imbalance. Antidepressent drug treatment did not have any effect on autonomic dysfunction.
Background: Altered cardiovascular autonomic nerve function with impaired autonomicl balance is found in Major Depressive Disorder(MDD). Objective: To assess some time domain measures of Heart Rate Variability (HRV) in MDD patients to observe their autonomic nerve function status.. Methods: This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during 2011on 60 patients of both sexes with Major Depressive disorder (MDD) aged 20-50 years. They were further subdivided into 30 drug naïve and 30 patients treated with anti depressive drug. Age, sex and BMI matched 30 apparently healthy subjects were control. The HRV parameters were recorded by 4 active channels, Polyrite-D. For statistical analysis ANOVA, independent sample t-test, were performed. Result: Mean R-R interval, SDNN,RMSSD ,PNN50%, NN50% were found significanty lower but heart rate was significantly higher in all MDD patients of both group compared to control.No significant differences were found in these parameters between treated and recently diagnosed patient. Conclusion: Cardiac autonomic nerve function was impaired in MDD patient which was characterized by reduced vagal tone. Antidepressive medication may not have any effect on impaired autonomic function in MDD.
This pilot study, within the limitations of its small size and variation between patients, found no apparent evidence that administration of nebulized salbutamol improved resuscitation of patients with acute OP insecticide self-poisoning. The data obtained provides a basis to design further studies to ultimately test the role of salbutamol in OP insecticide poisoning.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.