Despite progress in wound treatment including gene therapy, biological dresses and engineered skin equivalents, present treatment options for chronic wounds are restricted and not always effective. For example, inability to get consistent product from the introduced gene, biological covers may give rise to hypoxic conditions and engineered skin models are limited by their construction from substances which are hard to be degraded, and do not always result in complete replication into normal uninjured skin. A growing body of evidence suggests mesenchymal stem cells (MSCs), and their secreted growth factors and microvesicles, may potentiate the wound-healing process and as such their addition to novel wound-healing treatments may improve the efficacy of current therapeutic strategies. Recent studies report the ability of bone marrow-derived MSCs (BM-MSCs) to migrate and differentiate into skin cells in vivo. Therefore, this chapter aims to review the important concepts of wound healing at the cellular and kinetic level and the potential therapeutic strategies of MSCs through which to improve their treatment. Focus to this chapter will begin with a description of wound types, phases of healing process, followed by an outline of the role of MSC secretions in each phase, leading to potential novel treatment strategies and the requirements for a successful healing process.

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This study was designed to search the antitumor potential of Peganum harmala methanolic extracts and to evaluate their role in retardation the immunological side effects pre-and post-treatment which were carried out on 30 Albino male mice and included total and absolute count of leucocytes, micronucleus formation and phagocytic index of peritoneal cells. Our study showed that P. harmala derivatives have considerable antitumor activity with high efficacy in immobilization of the immunological side effects evoked following treatment with antitumor drug. In conclusion, P. harmala possess antitumor activity increases with concentrations increasing. Pre-treatment with these extracts exert higher retardation to the side effects than post-treatment.