metabolism in rodents. Also, several types of mushroom -Pleurotus Ostreatus 6 , Grifola Frondosa (maitake) 7 , Flammulina Velutips 7 , Lentinus Edodes (shitake) 8 , Ganoderma Lucidum 9 showed lowering effect of cholesterol synthesis or cholesterol absorption or by enhancement of fecal cholesterol excretion.

Introduction: Hs-CRP is a nonspecific marker of the inflammatory response has been associated with development of type 2 diabetes mellitus. Cardiovascular disease is a major consequence of diabetes. DM confers a 2-4 fold rise in cardiovascular risk compared with general population. One of the many modifiable risk factors for both cardiovascular disease and diabetes is diet. Fiber is an important dietary factor that may modify the risk of both diseases. Material & methods: The current study is an attempt to explore the association of dietary fiber on inflammatory marker, hs-CRP in type2 diabetic subjects. Total 80 diabetic subjects were included in this study of which 40 were taking more dietary fiber and 40 were taking relatively low dietary fiber. Serum hs-CRP was measured by chemiluminescent immunometric assay (DPC Biermann Gmbh., Germany). Nutrient information was calculated using a pretested food recall questionnaire prepared by nutritionists for usual Bangladeshi food articles. Results: Hs-CRP was significantly higher in subjects taking low dietary fiber. There was significant negative correlation between CRP of subjects taking high and low intake of dietary fiber. Conclusion: So, low dietary fiber consumption maybe a possible causal factor of raised CRP. Type 2 diabetic patients who took less dietary fiber in their diets had elevated blood CRP levels. DOI: http://dx.doi.org/10.3329/bjms.v11i2.11434 Bangladesh Journal of Medical Science Vol. 11 No. 02 April 2012: 117-120

Objective : To determine the association of blood pressure and other biochemical parameters with type 2 DM subjects. Methodology :This was an observational study with case control design was conducted in the Biomedical Research Group, Research Division, Bangladesh Institute of Research and Rehabilitation in Diabetes ,Endocrine Metabolic Disorders (BIRDEM), Dhaka Bangladesh, during the period of July 2008 to June 2009. A total of 153 subjects were included in study of which 63 belonged to T2 Diabetes Mellitus group and 90 were healthy Controls. Insulin glucose ratio were assayed in patients and controls and identified the association, using standardized assay methods. We also assessed the type -2 diabetic patients who had significantly raised Fasting blood sugar, insulin HOMA-B %= B cell function assessed by homeostasis model assessment to compared with the healthy controls. Correlation analysis of HOMA-B % with biochemical parameters, blood pressure, fasting and post prandial glucose also analysed.Results : Age of Control and type 2 DM subjects ( Mean±SD),P-value] were (46 ± 8.31) and (47 ±7.58), (P=0.326) respectively and BMI, among subject and control (kg/m 2) , (Mean ± SD), (24 ± 3.96, 25 ± 2.72 p=0.754). WHR [cm, (Mean±SD), p=<0.001], showed significant difference between T2 DM and healthy subjects. The median (range) of the glucose and insulin ratio of the study group, there was significant difference between Control vs. T2DM (p<0.001). Systolic blood pressure[S-BP, mean±SD] & Diastolic blood pressure [D-BP, mean±SD] were significant in T2DM as compared to control subjects {( p= 0.008) ( p= 0.003)} respectively ; Fasting plasma glucose levels [mmol/l, (Mean± SD)] , post prandial plasma glucose level [mmol/l, (Mean± SD)]and the HOMA%B level median (range) among subject and control of the study group [(8.27±2.19) , (11.79 ± 2.69), {71 ( 4.90 -391.30)}] were a significant difference in between Control vs type2 DM {(p <0.001), (p <0.001)and. (p <0.001)} respectively. Conclusion :In this study, boty systolic and diastolic blood pressure, blood glucose level and insulin status and WHR were found the significant parameters for maintaining type to DM under control condition. Development of hypertension cardio vascular disease and other complication can be prevented on keeping these parameters in normal level.

DOI: http://dx.doi.org/10.3329/ibmcj.v2i1.17312 IBMC J 2011; 2(1): 17-20

DOI: http://dx.doi.org/10.3329/bja.v9i2.15284 Bangladesh Journal of Anatomy 2011 Vol.9(2) pp.113-118

Dietary nutrients have shown overriding influence on insulin sensitivity and secretory status of diabetic subjects due to rapid lifestyle changes and urbanization. A case control study was conducted with 98 type 2 diabetic subjects and 97 healthy controls with BMI below obesity range to explore the association of dietary carbohydrate and body insulin status of nonobese diabetic subjects. Nutrient profile was taken by dietary recall method. Homeostasis Model Assessment (HOMA) was applied for measuring insulin status. Laboratory analysis and anthropometric measurements were done by standard methods. Statistical analysis was performed. Significant insulin secretory defect was found in diabetic group [Median (range), %; Control, 153 (65-285); DM, 50 (4-269)]. In diabetic group total carbohydrate [Median (range), gm/d; control, 235 (102-422); DM, 292 (151-454)], and fiber [Median (range), gm/d; control, 4.5 (2-18); DM, 6.2 (1.5-21)] consumption were found to be significantly higher than control. But no significant association was established between insulin secretions (HOMA%B) with carbohydrate consumption among the case group. So carbohydrate consumption does not influence β- cell serectory dysfunction in nonobese T2 DM patients. The possible potential effect of carbohydrate in insulin depression is not established. Key Words: Dietary Carbohydrate; Insulin Secretion; Nonobese Type 2 Diabetics DOI: http://dx.doi.org/10.3329/akmmcj.v2i2.8166 AKMMC J 2011; 2(2): 14-17