Background: During evaluation of thrombocytopenic patients, it is essential to identify the etiology, whether it is due to hypoproduction or hyperdestruction which will have impact on the management. Aim of study is to evaluate the variation and relationship of platelet indices in hypoproductive and hyperdestructive thrombocytopenia patients. Methods:A cross sectional study for a period of 2 months on Patients with thrombocytopenia. Platelet count, Plateletcrit (PCT), Platelet Distribution Width (PDW) and Mean Platelet Volume (MPV) and relevant clinical details of the thrombocytopenic patients were collected and tested for statistical significance by unpaired t test.Results: This study included 120 patients of thrombocytopenia who were classified into hypoproductive (26 cases) and hyperdestructive (94 cases). The mean platelet count in hypoproduction group is 75.9 ± 36.4 and in hyperdestruction group is 79.6 ± 36.3 with a P value of 0.64. The mean MPV in hypoproduction group is 10.17 ± 1.3 and in hyperdestruction group is 12.3 ± 0.9 with a significant P value of 0.05. The mean PDW in hypoproduction group is 19.7 ± 5.4 and in hyperdestruction group is 19.3 ± 4.2 with a P value of 0.7. The mean PCT in hypoproduction group is 0.06 ± 0.03 and in hyperdestruction group is 0.08 ± 0.1 with a P value of 0.2. Conclusion:Mean platelet volume may provide useful information in discriminating the hypoproductive and hyperdestructive thrombocytopenia. Interpretation of platelet indices can help the thrombocytopenic patients in the initial management and can avoid invasive investigations.

Xanthomas of the urinary bladder are rare. They may be associated with metabolic disorders. We hereby report a case of bladder xanthoma.

The significance of pretransplant anti-human leukocyte antigen antibody levels that are detectable by more sensitive platforms (including the Luminex platform) yet undetected by complement-dependent cytotoxicity (CDC) assay remains unclear. The aim of this study was to determine the clinical significance of the donor-specific antibody (DSA) assay Luminex crossmatch and its impact on short-term renal graft outcome such as acute rejections, graft survival, and graft function. The results of pretransplant DSA-lymphocyte crossmatching (LCXM) assay in 126 renal allograft recipients whose CDCs crossmatches were negative were retrospectively analyzed for correlation with posttransplant outcomes. Of the 126 recipients, 32 (25.4%) had pretransplant DSA positive. Statistically significant association was found between DSA-LCXM positivity with 14th day estimated glomerular filtration rate (eGFR) (P = 0.05), DSA Class I with 3rd (P = 0.014) and 6th month (P = 0.02) eGFR, DSA Class II with 14th day (P = 0.06) and 1st month (P = 0.10) eGFR, mean fluorescent intensity (MFI) DSA with 7th day (P = 0.08) and 14th day (P = 0.09) eGFR, and maximum MFI DSA with 7th day eGFR (P = 0.09). The posttransplant eGFR was higher at various time intervals in DSA-LCXM-negative patients as compared to DSA-positive patients. However, pretransplant DSA-LCXM results did not predict the rejection episodes, graft loss, and 1-year posttransplant 24 h urine protein. Pretransplant DSA detected by LCXM in patients with a negative CDC does not predict adverse short-term outcomes. However, the difference in posttransplant eGFR supports further investigation in long-term effects.

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BACKGROUNDLiterature reviews suggest that elderly are susceptible to severe complication due to anaemia compared to the younger ones. WHO defines that male <13 g/dL and female <12 g/dL should be termed as anaemic. Nearly 23.9% of the global population was anaemic. The prevalence of anaemia increases with age and that too females under 75 years were commonly affected compared to males. However, data regarding patterns of anaemia in Pondicherry is very less. This prompted us to study the morphological patterns and prevalence of anaemia for adults and geriatric population in a tertiary care hospital at Pondicherry.