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Nickel (II) sulfate hexahydrate is used for the first time as an efficient catalyst for the one-pot synthesis of a-aminophosphonates by three-component condensation reaction of aromatic aldehyde, primary amine, and diethylphosphite under mild and eco-friendly conditions. NiSO 4 Á6H 2 O was used with a catalytic amount of 5 mol% at room temperature, without solvent in the reaction. A series of the desired aaminophosphonates are obtained after a simple work-up procedure, with excellent yields (up to 92 %) within a short reaction time of 10-20 min in all cases. This heterogeneous catalyst was reused several times with the same activity. The present approach offers the advantages of a clean reaction, simple methodology, easy purification, and economic availability of the catalyst. Graphical Abstract NiSO 4 .6H 2 O 5 mol% Neat, rt 10-20 min R 1 H O + P O OEt OEt + NH 2 R 2 P H N R 1 O OEt OEt R 2 R 1 = Aryl, heteroaryl, ect R 2 = H, CH 3 , CF 3

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