Antituberculosis drugs are associated with a significant number of AR that can cause significant morbidity, prolonged hospital stay and even death. Our results show that alcoholism and levels of CD4 < 350 cells/mm(3) were significantly associated with a high risk of AR and hepatitis B and C and levels of CD4 < 350 cells/mm3 were also significantly associated with hepatotoxicity.
Atendendo às características do Mycobacterium tuberculosis (MT), o tratamento da tuberculose (TB) é feito com uma associação de vários fármacos, por um período de tempo alargado (≥ a 6 meses), cada um com potencial para provocar reacções adversas (RA). Estas podem acompanhar-se de significativa morbilidade e comprometer o tratamento da TB. Objectivos: Determinar a incidência, a gravidade e os factores de risco das principais RA induzidas pelos antibacilares, em doentes internados com TB em tratamento. Material e métodos: Análise retrospectiva dos registos clínicos dos doentes internados no Serviço de
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