Data availability statement:The data that support the findings of this study are available in the published literature also cited in the present manuscript.
Massive vaccination is very important to end the coronavirus disease 2019 (COVID-19) pandemic. This study determined the willingness to receive a COVID-19 vaccine by the university students of Bangladesh and identified their apprehension about the effectiveness and safety of COVID-19 vaccines. Students were invited to complete an online cross-sectional survey (April 3 to June 10, 2021) to explore the intention to receive a COVID-19 vaccine and other factors regarding the responsiveness of the COVID-19 vaccine. Among the 191 respondent students, 52.9% willingly agreed to receive a vaccine, where the remaining was either not decided yet (27.7%) or was not intended to get vaccinated (15.7%). The odd of getting a vaccine were only 1.15. About 83.2% of students were conscious about the severity of COVID-19 and many students responded that they are well-versed about vaccine activity (67.5%) and risk factors (66%). Among the approved vaccines, most students preferred the Oxford-AstraZeneca COVID-19 vaccine ChAdOx1 (38.7%) and Pfizer-BioNTech COVID-19 vaccine BNT162b2 (34%). As some of the students still have lesser intent to accept vaccines, public health officials need to be more proactive to focus on vaccine safety and benefits to enhance vaccine coverage among university students of Bangladesh.
Crimean-Congo hemorrhagic fever (CCHF) is a viral disease caused by the Crimean-Congo hemorrhagic fever virus (CCHFV) of the Nairovirus genus. CCHF has occurred endemically in several regions of Africa, Southern Europe, and Central and Southeast Asia, with a case fatality rate of 5 to 80%. The World health organization enlisted CCHF as one of the top prioritized diseases for research and development in emergency contexts that making it a public health concern as no effective vaccine is available till date. Therefore, the present study aims to develop an effective multi-epitope subunit vaccine using immunoinformatics and reverse vaccinology approach against this virus. The B-cell and T-cell epitopes were predicted from structural and non-structural proteins, and filtered by immunogenicity, allergenicity, toxicity, conservancy, and cross-reactivity. The computational analysis revealed that the epitopes could induce an adequate immune response and had strong associations with their respective human leukocyte antigen (HLA) alleles with 98.94% of total world population coverage. Finally, the vaccine with 427 amino acids was constructed by connecting 8 cytotoxic T-lymphocytes, 4 helper T-lymphocytes, and 10 B-cell epitopes with appropriate linkers and β-defensin as an adjuvant. The antigenicity, allergenicity, solubility, and physiochemical properties of the vaccine were evaluated, followed by structural modelling, refinement, and validation. In addition, molecular docking and molecular dynamic simulations revealed a robust binding affinity and stability of the vaccine-immune receptor complex. Moreover, the codons were optimized for its higher expression in Escherichia coli ( E. coli ) K12 strain followed by in silico cloning. The proposed subunit vaccine developed in this study could be a potential candidate against CCHFV. However, further experimental validation is required to ensure the immunogenicity and safety profile of the proposed vaccine for combating and eradicating CCHFV. Supplementary Information The online version contains supplementary material available at 10.1007/s10989-022-10430-0.
The global emergence of the recently discovered COVID-19 (Coronavirus disease 2019; SARS-CoV-2) has already shown its devastating effects on almost the entire world by causing huge numbers of death cases and rupturing the whole economy as well as social communication. South Asia, a region that comprises mostly of least developed and developing countries (Afghanistan, Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka) with overpopulation, illiteracy, poverty, lack of awareness, lack of hygiene, inadequate health care facilities, is still struggling to fight against this virus and facing the consequences with over 8.5 million confirmed cases including 130,636 deaths till the 20th October. Prompt and proper protective measures, good health care systems, and conscious people are the keys to reducing the severe impacts of this pandemic situation, and most of the countries in this region lack all of this. Considering this, it will not be a surprise if the pandemic takes its full shape in these countries and recent evidence also suggest that the situation is already on its way to reach the peak. However, the pandemic nature in South Asia also demonstrates that strict measures by the government and co-operation from the people can protect a country from the impacts of the virus, whereas lack of these can lead to the next heat point. This review demonstrates and compares the impact of COVID-19 in the mass population of South Asia which could support the government and scientific community to take proper protective measures against this global pandemic and better prepare the community for future challenges. Moreover, good health care systems, public health infrastructure, and up to date information on COVID-19 outbreaks in this region will help to combat this pandemic and create more sustainable and resilient healthy societies in South Asia. Bioresearch Commu. 7(1): 973-981, 2021 (January)
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