one of the major drawbacks of cheminformatics is a large amount of information present in the datasets. In the majority of cases, this information contains redundant instances that affect the analysis of similarity measurements with respect to drug design and discovery. therefore, using classical methods such as the protein bank database and quantum mechanical calculations are insufficient owing to the dimensionality of search spaces. In this paper, we introduce a hybrid metaheuristic algorithm called cHHo-cS, which combines Harris hawks optimizer (HHo) with two operators: cuckoo search (cS) and chaotic maps. the role of cS is to control the main position vectors of the HHo algorithm to maintain the balance between exploitation and exploration phases, while the chaotic maps are used to update the control energy parameters to avoid falling into local optimum and premature convergence. feature selection (fS) is a tool that permits to reduce the dimensionality of the dataset by removing redundant and non desired information, then fS is very helpful in cheminformatics. FS methods employ a classifier that permits to identify the best subset of features. the support vector machines (SVMs) are then used by the proposed cHHo-cS as an objective function for the classification process in FS. The CHHO-CS-SVM is tested in the selection of appropriate chemical descriptors and compound activities. Various datasets are used to validate the efficiency of the proposed CHHO-CS-SVM approach including ten from the UCI machine learning repository. Additionally, two chemical datasets (i.e., quantitative structure-activity relation biodegradation and monoamine oxidase) were utilized for selecting the most significant chemical descriptors and chemical compounds activities. the extensive experimental and statistical analyses exhibit that the suggested CHHO-CS method accomplished much-preferred trade-off solutions over the competitor algorithms including the HHO, CS, particle swarm optimization, moth-flame optimization, grey wolf optimizer, Salp swarm algorithm, and sine-cosine algorithm surfaced in the literature. the experimental results proved that the complexity associated with cheminformatics can be handled using chaotic maps and hybridizing the meta-heuristic methods. The prediction and analysis of molecules are essential tasks in cheminformatics, which use methods from mathematics and computer science to enhance their performance. The implementation of these methods depends on databases. The processes that generate most of the affectations are the storage and retrieval of molecular structures and properties (e.g., pharmacogenomics data). Typically, the behavior of the compounds can be investigated using molecular analysis. The molecular analysis helps to develop and test molecules for decreasing the effects of specific diseases 1. One drawback associated with cheminformatics is the exponential increment of the search space owing to features in the dataset 2. However, cheminformatics is still being widely used in drug design, where ...
Smart monitoring and assisted living systems for cognitive health assessment play a central role in assessment of individuals’ health conditions. Autistic children suffer from some difficulties including social skills, repetitive behaviors, speech and nonverbal communication, and accommodating to the environment around them. Thus, dealing with autistic children is a serious public health problem as it is hard to determine what they feel with a lack of emotional cognitive ability. Currently, no medical treatments have been shown to cure autistic children, with most of the social assistive research to date focusing on Autism Spectrum Disorder (ASD) without suggesting a real treatment. In this paper, we focus on improving cognitive ability and daily living skills and maximizing the ability of the autistic child to function and participate positively in the community. Through utilizing intelligent systems based Artificial Intelligence (AI) and Internet of Things (IoT) technologies, we facilitate the process of adaptation to the world around the autistic children. To this end, we propose an AI-enabled IoT system embodied in a sensor for measuring the heart rate to predict the state of the child and then sending the state to the guardian with feeling and expected behavior of the child via a mobile application. Further, the system can provide a new virtual environment to help the child to be capable of improving eye contact with other people. This way is represented in pictures of these persons in 3D models that break this child’s fear barrier. The system follows strategies that have focused on social communication skill development particularly at young ages to be more interactive with others.
Feature selection (FS) is one of the basic data preprocessing steps in data mining and machine learning. It is used to reduce feature size and increase model generalization. In addition to minimizing feature dimensionality, it also enhances classification accuracy and reduces model complexity, which are essential in several applications. Traditional methods for feature selection often fail in the optimal global solution due to the large search space. Many hybrid techniques have been proposed depending on merging several search strategies which have been used individually as a solution to the FS problem. This study proposes a modified hunger games search algorithm (mHGS), for solving optimization and FS problems. The main advantages of the proposed mHGS are to resolve the following drawbacks that have been raised in the original HGS; (1) avoiding the local search, (2) solving the problem of premature convergence, and (3) balancing between the exploitation and exploration phases. The mHGS has been evaluated by using the IEEE Congress on Evolutionary Computation 2020 (CEC’20) for optimization test and ten medical and chemical datasets. The data have dimensions up to 20000 features or more. The results of the proposed algorithm have been compared to a variety of well-known optimization methods, including improved multi-operator differential evolution algorithm (IMODE), gravitational search algorithm, grey wolf optimization, Harris Hawks optimization, whale optimization algorithm, slime mould algorithm and hunger search games search. The experimental results suggest that the proposed mHGS can generate effective search results without increasing the computational cost and improving the convergence speed. It has also improved the SVM classification performance.
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