Flood is considered to be the most common natural disaster worldwide during the last decades. Flood hazard potential mapping is required for management and mitigation of flood. The present research was aimed to assess the efficiency of analytical hierarchical process (AHP) to identify potential flood hazard zones by comparing with the results of a hydraulic model. Initially, four parameters via distance to river, land use, elevation and land slope were used in some part of the Yasooj River, Iran. In order to determine the weight of each effective factor, questionnaires of comparison ratings on the Saaty's scale were prepared and distributed to eight experts. The normalized weights of criteria/parameters were determined based on Saaty's nine-point scale and its importance in specifying flood hazard potential zones using the AHP and eigenvector methods. The set of criteria were integrated by weighted linear combination method using ArcGIS 10.2 software to generate flood hazard prediction map. The inundation simulation (extent and depth of flood) was conducted using hydrodynamic program HEC-RAS for 50-and 100-year interval floods. The validation of the flood hazard prediction map was conducted based on flood extent and depth maps. The results showed that the AHP technique is promising of making accurate and reliable prediction for flood extent. Therefore, the AHP and geographic information system (GIS) techniques are suggested for assessment of the flood hazard potential, specifically in no-data regions.