The objective of this study was to evaluate inflammatory markers as predictors of fertility after varicocelectomy and to develop a prediction model. This prospective cohort was conducted on patients with varicoceles who were presented to the clinic of Imam Reza hospital of Tehran during 2019-2020. Semen analysis, complete blood count (CBC), and scrotal ultrasonography was requested. Patients with abnormalities of semen analysis were chosen as candidates for varicocelectomy. 6 months after the operation, semen analysis was repeated. Hematologic and semen analysis parameters were recorded at baseline and follow-up visits. Treatment success was defined as 50% increase in total motile sperm count (TMSC) in cases with preoperative TMSC> 5 million/cc or 100% increase in TMSC in cases with preoperative TMSC< 5 million/cc. Patients were then categorized into two groups based on treatment success and statistical analysis was performed on these two groups. 124 infertile patients with varicocele were evaluated in our study. 52 patients (41.93%) showed improvements in semen analysis after varicocelectomy. After univariate and multivariate analysis three parameters were used in our predictive model as body mass index (BMI)>23.70 kg/m2 (4 scores), neutrophil-lymphocyte ratio (NLR) >1.80 (3 scores), and TMSC<14.69 million (2 scores). A cut-off value of 5 was associated with an 87.5% sensitivity and an 84.6% specificity for the prediction of failure of varicocelectomy. Varicocelectomy can improve semen analysis parameters in almost all infertile men with varicocele. Using BMI, NLR, and baseline TMSC as the suggested scoring system can predict the success of varicocelectomy for improving fertility and determine the appropriate infertile candidates for surgery.
The engineers use various softwares for observation processing and GPS networks, generally everyone who uses a device, he uses softwares with the same brand for the processing of it GPS processing networks by defined default parameters and models. The most outstanding issue is that, it should be understood, the application of which kinds of softwares will help us to gain the desirable accuracy and whether the accuracy of coordinate estimation is acceptable in all commercial softwares or not. In this article, we compared a series of softwares which engineers use for their data processing with powerful scientific software that meanwhile it is too hard and time consuming to learn it. We have considered accuracy and validity of scientific software, which gives acceptable results, as a baseline to see how much errors and difference is between this software and the commercial softwares, so we selected Bernese as a scientific software and LGO, Ashtech Solutions, CGO softwares as commercial softwares and we analyzed them and compared the applied models of the softwares with each other. To do so, we choose a GPS network from Tehran city and discussed it, in order to evaluate the measured accuracy for baselines and also coordinate system that after data processing, it was understood that if the polygon of a network is small, commercial softwares can be utilized with very high acceptable accuracies and even by Ephemerides Precise data, their accuracy will increase more, but if our network is more extended and bigger, there is no other choice except using scientific softwares to calculate coordinate that performs a processing by many parameters.
Oral acetazolamide can reduce the irritative voiding symptoms and improve the quality of life which is concomitant with an increase in urinary pH.
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