Radiative hyperthermia is a clinically applied cancer treatment modality where antenna design is crucial to achieving therapeutic goals. Serving as the building block of a phased‐array configuration, antennas are typically arranged in a cylindrical or elliptical array called applicator. This short communication proposes an elliptical phased array applicator based on a compact, UWB design from the category of double‐ridged horn antennas customized for hyperthermia systems. The performance of the antenna, named open ridged‐waveguide, has been experimentally assessed based on the quality metrics of the hyperthermic community. The proposed design achieves an ultra‐wideband range of operation from 400 to 800 MHz with an aperture size of 3 by 4 cm. Moreover, thanks to the shielding provided by the metallic housing, the design proves good isolation better than −30 dB throughout the band. The power deposition capability of the proposed applicator followed by the thermal analysis is also investigated for a realistic head and neck patient model. The results indicate very good quality metrics achieved in the treatment planning of the patient.
Combining radiotherapy (RT) with hyperthermia (HT) has been proven effective in the treatment of a wide range of tumours, but the combination of externally delivered, focused heat and stereotactic radiosurgery has never been investigated. We explore the potential of such treatment enhancement via radiobiological modelling, specifically via the linear-quadratic (LQ) model adapted to thermoradiotherapy through modulating the radiosensitivity of temperature-dependent parameters. We extend this well-established model by incorporating oxygenation effects. To illustrate the methodology, we present a clinically relevant application in pediatric oncology, which is novel in two ways. First, it deals with medulloblastoma, the most common malignant brain tumour in children, a type of brain tumour not previously reported in the literature of thermoradiotherapy studies. Second, it makes use of the Gamma Knife for the radiotherapy part, thereby being the first of its kind in this context. Quantitative metrics like the biologically effective dose (BED) and the tumour control probability (TCP) are used to assess the efficacy of the combined plan.
Antennas are the building block of radiative hyperthermia (HT) applicators. This study proposes a compact UWB antenna specifically tailored to meet the requirements for deep HT array applicators. The proposed Open Ridged‐Waveguide (ORWG) antenna, which is an adaptation of a double‐ridged horn antenna, operates over the frequency band of 400–800 MHz. It was experimentally assessed as a single element. The quality metrics considered were reflection coefficient, penetration depth, effective field size (EFS), and mutual coupling. The design shows a 75.5% fractional bandwidth with a reflection coefficient measured to be below −10 dB from 367 up to 820 MHz. The EFS is greater than the physical dimensions of the 3‐by‐4 cm aperture. The mutual coupling between two adjacent elements in the array, measured in a flat phantom arrangement, is lower than −30 dB throughout the entire band. The antenna's performance was further tested in two deep HT scenarios in order to assess the mutual coupling and focussing abilities while in the array configuration. To this end, phased array applicators consisting of 10 and 16 ORWG antennas were simulated in CST, and the results are presented for a homogeneous cylindrical muscle phantom and a realistic patient model, respectively. The good agreement between the simulated and measured results suggests that the antenna can be successfully used for HT.
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