Driven by successful pilot projects in supply chain and logistics, Blockchain has become one of the industry’s latest technology hypes. In this paper, we cut through the hype and shed light on the expectations of industry professionals towards the benefits and challenges of Blockchain. Also, we categorize current Blockchain applications that are expected to provide tangible benefits for supply chain and logistics processes. To explore such potentials, we argue that companies should gain own first-hand experiences through small-scale experiments.

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Blockchain is expected to have a transformational effect on supply chain and logistics due to its promise to improve the information flow between the supply chain partners. However, despite their high hopes, incumbent companies from supply chain and logistics are still struggling to deliver on this promise. In this explorative, qualitative interview study, we identify how incumbent companies try to make use of Blockchain in supply chain and logistics and we also analyze the barriers hampering them. The analysis of twenty-four semi-structured expert interviews and extensive secondary data collates a comprehensive picture of incumbent companies' activities around Blockchain adoption. We find that companies use Blockchain to drive digital transformation, constitute new business models and unify the industry through consortia. The main barriers to such solutions are a lack of technological usability and long-term uncertainties. The results of our study provide evidence for theoretical constructs and guide managerial practice. INDEX TERMS Blockchain, decision making, logistics, supply chain management, technology management.

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Host cell proteases such as TMPRSS2 are critical determinants of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) tropism and pathogenesis. Here, we show that antithrombin (AT), an endogenous serine protease inhibitor regulating coagulation, is a broad‐spectrum inhibitor of coronavirus infection. Molecular docking and enzyme activity assays demonstrate that AT binds and inhibits TMPRSS2, a serine protease that primes the Spike proteins of coronaviruses for subsequent fusion. Consequently, AT blocks entry driven by the Spikes of SARS‐CoV, MERS‐CoV, hCoV‐229E, SARS‐CoV‐2 and its variants of concern including Omicron, and suppresses lung cell infection with genuine SARS‐CoV‐2. Thus, AT is an endogenous inhibitor of SARS‐CoV‐2 that may be involved in COVID‐19 pathogenesis. We further demonstrate that activation of AT by anticoagulants, such as heparin or fondaparinux, increases the anti‐TMPRSS2 and anti‐SARS‐CoV‐2 activity of AT, suggesting that repurposing of native and activated AT for COVID‐19 treatment should be explored.

Purpose The purpose of this paper is to explore how big-picture sustainability strategies are translated into tangible product development efforts. The authors assert that most sustainable products currently remain confined to niche markets and do not permeate the mainstream. The authors propose that there is a missing link between strategic sustainability goals and operational product development initiatives. The authors establish a path to bridging this gap. Design/methodology/approach The manuscript is based on a qualitative research design with a sample of 32 companies. Data were collected from semi-structured interviews with product developers as well as secondary data analysis. Findings The authors delineate three empirically derived approaches firms from the sample pursue to develop sustainable products. The authors identify a phenomenon that the authors’ call the fallacy of trickle-down product sustainability. The authors find that only one of the three approaches – codification – is equipped to successfully turn strategic sustainability targets into authentic sustainable products. Practical implications This study provides an actionable guide to executives and product developers with respect to bridging the gap between often elusive sustainability aspirations and tangible product improvements via the process of rigorous codification. Originality/value This study provides a novel and unique perspective into strategy, sustainability and product development. The authors synthesize the extant literature on sustainable product development, juxtapose the emergent structure with primary interview data, and elaborate the resource-based view (RBV) to provide theoretical and practical implications. The authors establish scalability as the missing RBV capability of many attempts toward mass–market compatibility of more sustainable products.