Transition‐metal‐catalyzed C−H functionalization and photoredox nickel dual catalysis have emerged as innovative and powerful avenues for the synthesis of C‐branched glycosides. These two concepts have been recently established and provide efficient and mild methods for accessing a series of valuable complex C‐branched glycosides of great interest. Herein, recent developments in the synthesis of C‐branched aryl/alkenyl/alkyl glycosides through these two approaches are highlighted.
Access to unprotected 2‐cyano‐glycals via a mild palladium‐catalyzed cyanation of protecting groups‐free 2‐iodoglycals in aqueous media has been developed. Diverse glycal substrates including disaccharide‐type were successfully obtained in good to excellent yields. These unprotected 2‐cyano‐glycal scaffolds were successfully derivatized to different C2‐glycoanalogues.
Directed palladium-catalyzed C–H functionalisation of C2-amido glycals onto the anomeric position is described as a novel route to C-aryl/alkenylglycosides.
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