SUMMARYThe smoking questionnaire (SQ), a multidimensional questionnaire covering the major dimensions of cigarette smoking, was developed to address the heterogeneity in the assessment of smoking exposure. It consists of eight questions and can be completed within a few minutes. Test-retest reliability of the SQ and concurrent validity with the Behavior Risk Factor Surveillance System (BRFSS) 2011 questionnaire were examined in a clinical study conducted in adult US current menthol cigarette smokers. The SQ and the BRFSS were self-administrated twice before and after randomization with a 6-day interval. The inter-temporal analyses included current smokers aged 22 to 66 years who completed the SQ at both timepoints. The percent agreement of items and 95% confidence intervals were calculated for the comparisons between the two timepoints and between the SQ and the BRFSS questionnaire. To evaluate the feasibility of the SQ and to capture subjects' opinions about the SQ, a meta-questionnaire was administrated. High test-retest reliability levels (percent agreement of > 70 to 100% between the two timepoints) were found for SQ smoking behavior items, in particular for items related to current smoking status, 100-cigarettes lifetime, regular smoking, age of initiation and preferred brand. Moderate (55% agreement) to high test-retest reliability (84% agreement) was found for daily consumption of manufactured cigarettes. The comparison between the SQ and the BRFSS 2011 showed a high concurrent validity (98 to 100% agreement). The SQ was completed on average in 3 to 4 min and was assessed as easy to use. The findings demonstrate that the SQ is reliable in smokers and a practical tool to assess smoking exposure in clinical studies. [Beitr. Tabakforsch. Int. 27 (2017) RESUMELe questionnaire sur le tabagisme (SQ), questionnaire multi-dimensionnel couvrant les principales dimensions du tabagisme, a été développé afin de remédier à l'hétéro-généité dans l'évaluation de l'exposition au tabagisme. Il se compose de huit questions et peut être complété en quelques minutes. La fiabilité test-retest du SQ ainsi que la validité concomitante avec le questionnaire du Système de surveillance des facteurs de risque comportementaux (BRFSS) de 2011 ont été examinées dans une étude clinique menée chez des adultes américains, fumeurs de cigarettes au menthol. Le SQ et le BRFSS ont été autoadministrés deux fois, avant et après randomisation, avec un intervalle de 6 jours. Les analyses inter-temporelles comprenaient des fumeurs actuels âgés de 22 à 66 ans qui ont rempli le SQ aux deux points de mesure. La concordance en pourcentage des items et les intervalles de confiance à 95% ont été calculés pour les comparaisons entre les deux points de mesure, ainsi qu'entre le SQ et le BRFSS. Afin d'évaluer la faisabilité du SQ et pour saisir les opinions des sujets sur le SQ, un méta-questionnaire a été administré. Des niveaux élevés de fiabilité test-retest (concordance en pourcentage > 70-100% entre les deux points de mesure) ont été trouvés pour ...
Background: Smoking cessation reduces the risk of developing smoking-related diseases. Although smoking prevalence has declined, many smokers continue smoking cigarettes. Switching to less harmful smoke-free alternatives such as the Tobacco Heating System (THS), a non-combustible tobacco-based product, is an approach to reduce the harm caused by cigarettes. Methods: We conducted a 12-month clinical study with 984 adult smokers randomized to either continue smoking or to use THS. We assessed the trajectories of biomarkers of potential harm (BoPH) known to be reversible upon smoking cessation, as one measure of different pathways involved in the pathogenesis of cardiovascular or respiratory diseases, and carcinogenicity. Beneficial impact on 8 key BoPHs was used as a proxy to evaluate harm reduction.Results: At 12 months, comparison of the 8 BoPH levels between the predominant THS use and cigarette smoking groups showed differences in favor of THS switching when contextualized to the changes reported for smoking cessation. Conclusions: Our results likely indicate a further decrease in carcinogenicity and relative risk of developing cardiovascular or respiratory diseases for smokers switching to THS compared to those who would continue smoking. These results provide additional evidence of the harm reduction potential of predominant THS use. Trial Registration clinicaltrials.gov Identifier: NCT02649556 Date of registration: 07/01/2016 (dd/mm/yyyy)(https://clinicaltrials.gov/ct2/show/NCT02649556)
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