We report a case of E. histolytica, which is a rare parasitic infection in North America. A 66-year-old Ecuadorian female had an intermittent six-month history of bloating, explosive diarrhea and significant abdominal distension. Histopathological specimen obtained via colonoscopy revealed colitis due to E. histolytica. Diagnosis is best accomplished by the combination of serology or antigen testing together with identification of the parasite in the stool or extra-intestinal sites or histologic examination when necessary. With medical tourism and an increase of immigrants from South and Central America, disease endemic to those areas should always be considered.
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