BackgroundTeicoplanin is a glycopeptide antibiotic that is widely used in clinical practice for the treatment of infections caused by drug-resistant Gram-positive bacteria. The aim of this study was to analyze plasma teicoplanin concentrations to determine the percentage of patients in whom therapeutic concentrations of teicoplanin were achieved in clinical practice.Materials and MethodsThe plasma teicoplanin concentrations of hospitalized patients receiving treatment at a teaching hospital were retrospectively analyzed. The target level was defined as a plasma teicoplanin concentration of 10 mg/L or greater, since this was generally regarded as the lower limit of the optimal concentration range required for the effective treatment of a majority of infections.ResultsPatients with sub-optimal (< 10 mg/L) plasma teicoplanin concentrations constituted nearly half of the total study population. The majority of these patients received the recommended loading dose, which were three 400 mg doses administered every 12 hours. Sub-group analysis showed a trend that the group receiving loading dose was more likely to reach the optimal teicoplanin concentration.ConclusionsThe data revealed that a significant proportion of patients in clinical practice achieved only sub-optimal teicoplanin concentrations, which emphasizes the importance of the mandatory use of loading dose and routine therapeutic drug monitoring. Treatment reassessment and simulation of individual dose regimens may also be necessary to achieve optimal drug concentrations.
In this study, engineering property tests were conducted for cement milk used as a filling materials in the bored piles method. For this purpose, various water/cement ratio specimens were produced on the basis of standard specimen specified in highway corporation specifications. The unconfined compressive strength, point load strength, elasticity modulus, poisson's ratio test was performed according to the age. As a test result, injection height for productions of cement milk specimens was defined ratios. Correlation coefficient K of the unconfined compressive strength and point load strength were K7 = 4.55∼13.65 in age 7 days, and K28 = 5.28∼16.84 in age 28 days. When water / cement ratio is 65-150%, the elastic modulus and Poisson's ratio significantly increased and decreased regardless of age. In addition, the formulae were proposed for unconfined compressive strength, point load strength, a correlation coefficient of unconfined compressive strength, point load strength, elastic modulus, and poisson's ratio for each age.
In this study, a jointless bridge that integrates the superstructure and abutment without installing an expansion joint was analyzed. An example of a jointless bridge that has been introduced in Korea since 2009. Owing to the short period of use and lack of experience in design, construction, and maintenance, there is insufficient information regarding the long-term behavior of jointless bridges. When analyzing numerous bridges, the numerical analysis model must maintain the numerical values used and ensure the convenience of model construction. In this study, sensitivity analysis was performed to select a numerical model for various types of jointless bridges using commercial finite element programs, MIDAS Civil and ABAQUS 2018. According to a solid element-based model, we analyzed the mean and maximum relative errors between structural models. Consequently, it was found that the beam element-based model exhibits a significantly small relative error in comparison to the shell element, where a relatively large error was recorded. Therefore, the optimal numerical analysis model, a practical model that maintains the similarity and precision of the displacement shape cause by relative error, was judged to be the most suitable for jointless bridges based on the shell element.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.