Introduction: Mesenteric cysts are rare benign lesions. They usually remain asymptomatic and in most cases are incidentally discovered. However, they can reach large dimensions conditioning pain, abdominal distension or sensation of an abdominal mass. The definitive diagnosis is often made during surgery that should involve total removal of the lesion. Knowledge of these lesions is important because of the existence of complications associated with ineffective surgery. This paper reports the surgical treatment of a large mesenteric cyst. Case Report: We report a 20-year-old male with an history of abdominal distension without pain, nausea or vomits. The image examinations revealed a large cystic mass involving the entire abdominopelvic cavity. The patient underwent an exploratory laparotomy and the cyst was excised. The histological examination revealed a serous cyst 33 cm in diameter, without evidence of malignancy. Conclusion: Mesenteric cysts are uncommon lesions that can present asymptomatically or with nonspecific symptoms. Complete resection of the cyst could be challenge but is still the best therapy.
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