Background: Sick sinus syndrome (SSS) is a common disease and causes increased risk of death and cardiovascular disease in patients. When patients with SSS refuse pacemaker therapy because of contraindications or financial or personal reasons, drug treatment is needed, especially in developing countries.
Objective:The study assessed the therapeutic effects of calcium dibutyryladenosine cyclophosphate (CDC) on patients with SSS.
Method:We studied 65 inpatients with SSS who were without permanent pacemaker implantation and were treated with or without CDC at random. The patients who received intravenous injection with CDC in addition to conventional treatment were considered as treatment group. The patients who only received conventional treatment were considered as control group. After 12 days administration, manifestations, 12-lead electrocardiographic and 24-hour Holter monitor were compared respectively.Result: After the treatment with CDC, 91.2% of the patients reported a significant overall improvement of symptoms, while patients recovered clearly compared with the control group (P<0.01). CDC markedly improved heart rate measured by 24-hour Holter monitor in patients with SSS compared with the control group (P<0.01).
Conclusion:CDC showed significant therapeutic effects on patients with SSS and could be an affordable and expected alternative therapy.
We set out to assess whether the preoperative prediction of patient-prosthesis mismatch by an algorithm popularised by Pibarot et al. is accurate compared to PPMM defined as AVA <0.85 cm2/m2 (‘any PPMM’) or as AVA <0.65cm2/m2 (‘severe’ PPMM).
We studied 37 patients (16 female), with mean age 72.3 +/− 8.4 years, who had unplanned SAVR during 2019. By echo, 17 (19.7%) patients had severe PPMM (mean AVA (SD) = 0.55 (0.04) cm2). For the 0.85cm2/m2 cut-off, 14/37 patients (37%) had PPMM (mean AVA (SD) 0.70 (0.15) cm2. By the Pibarot algorithm, 21 (56.7%) patients were predicted to have any PPMM and 10 (27%) severe PPMM.
The preoperative algorithm for the avoidance of patient prosthetic mismatch does not accurately identify patients who have postoperative PPMM as defined by echocardiography. Further refinements of the algorithm seem necessary before it can be used widely in clinical practice.
The purpose of this study was to subject patients with persistent low backache who were unresponsive to 4 weeks of conservative management to imaging in the form of MRI Lumbo-Sacral spine and study the MRI findings and to evaluate the age and sex distribution and level and number of discs affected in degenerative lumbar disc disease by MRI.
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