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Mountains are highly sensitive to the effects of climate change, including extreme short- and long-term weather phenomena. Therefore, in spite of relatively high annual precipitation totals, mountains might become endangered by droughts. The paper presents drought trends in the Polish Carpathians located in Central Europe. Data from the period 1991–2020 from 12 meteorological stations located in various vertical climate zones of the mountains were used to define drought conditions using the following indices: Standardized Precipitation (SPI), Standardized Precipitation Evapotranspiration (SPEI), Relative Precipitation (RPI) and Sielianinov. Additionally, four forest drought indices were used in order to estimate the impact of drought on beech as a typical Carpathian tree species, i.e., the Ellenberg (EQ), Forestry Aridity (FAI), Mayr Tetratherm (MT) and De Martonne Aridity (AI) indices. Statistically significant but weak trends were obtained for the 6-month SPI for four stations (indicating an increase in seasonal to mid-term precipitation), for the 1-month SPEI for three stations, for the 3-month SPEI for four stations, and for MT for all stations (indicating an increase in drought intensity). The analysis of dry month frequency according to particular indices shows that at most of the stations during the last decade of the study period, the frequency of dry months was much higher than in previous decades, especially in the cold half-year. Two zones of the Polish Carpathians are the most prone to drought occurrence: the peak zone due to the shift in climatic vertical zones triggered by the air temperature increase, and the forelands and foothills, together with basins located about 200–400 m a.s.l., where the mean annual air temperature is the highest in all the vertical profile, the annual sums of precipitation are very diversified, and the conditions for beech are already unfavorable.

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Background: The outbreak of coronavirus disease (COVID-19) has posed a major threat to people's lives across the globe. It has drastically changed the way we perceive this world. A paradigm shift was observed globally as the world’s emphasis shifted to testing, diagnosis, treatment, and developing a coronavirus cure. Clinical trials were also not untouched by this. The coronavirus pandemic has abhorrently affected the day-to-day clinical trial activities at sites. Methods: The status of various ongoing clinical trials was assessed through a literature search, which also includes clinical trial portals. Our evaluations were based on these observations. Results: Multiple challenges were present in clinical trials as recruitment, retention, the safety of trial subjects, protocol compliance, and this made the world to re-think to incorporate newer strategies and to cope with this untoward situation. Conclusion: Digitalization of clinical trials as virtual management of adverse events, remote monitoring visits, and web-based consulting with trial subjects are potential directions that can be applied to better manage clinical trials worldwide.